Linked Life Data

9511166

Source:http://linkedlifedata.com/resource/pubmed/id/9511166

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1998-4-23
pubmed:abstractText
The relationship between performance on cognitive tasks and circulating levels of lead in blood and accumulated levels of lead in bone was examined in 141 middle-aged and elderly men from a longitudinal study of aging. The mean (SD) blood lead level was low [5.5 (3.5) micrograms/dl], and mean patella and tibia lead levels were 31.7 (19.2) and 22.5 (12.2) micrograms/g bone mineral, respectively. Cognitive tests measured attention, perceptual speed, memory, language, and spatial copying. Regression models, adjusted for age and education, demonstrated that men with higher levels of blood lead recalled and defined fewer words, identified fewer line-drawn objects, and required more time to attain the same level of accuracy on a perceptual comparison test as men with the lowest level of blood lead. Men with higher levels of blood and bone (tibia) lead copied spatial figures less accurately; men with higher levels of bone (tibia) lead had slower responses for pattern memory. These findings suggest that low levels of lead contribute to impairments in cognitive function among elderly men.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0892-0362
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
19-27
pubmed:dateRevised
2009-10-26
pubmed:meshHeading
pubmed:articleTitle
Relations of bone and blood lead to cognitive function: the VA Normative Aging Study.
pubmed:affiliation
Department of Medicine, Brigham and Women's Hospital, Channing Laboratory, Harvard Medical School, Boston, MA 02115, USA. remar@gauss.bwh.harvard.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.