Linked Life Data

9508737

Source:http://linkedlifedata.com/resource/pubmed/id/9508737

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4-5
pubmed:dateCreated
1998-3-19
pubmed:abstractText
This paper first summarizes the studies indicating that the immunotoxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), notably atrophy of the thymus and suppression of the thymus-dependent immunity, are mediated by binding to a soluble cytosolic protein, the aryl hydrocarbon (Ah) or TCDD receptor, present in the thymus in the epithelial cells. On the basis of a common receptor-mediated mechanism of toxic action, the relative (immuno)toxicity of individual PCDDs and PCDFs can be expressed relative to TCDD (i.e., toxic equivalents). Next, studies on TCDD-induced immunosuppression and impaired host resistance, and lowest observed effects levels of TCDD resulting in immune alterations, are summarized. Immune investigations performed in man are discussed and it is concluded that, for risk assessment purposes, further studies are necessary to determine the sensitivity of the human immune system to TCDD. For this purpose, a recent study is summarized in which the sensitivity of the human thymus to TCDD is investigated in so-called severe combined immunodeficient (SCID) mice in which human thymus grafts were transplanted. This study indicates that the human thymus and the Wistar rat thymus display a similar sensitivity to TCDD.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0270-3211
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
275-84
pubmed:dateRevised
2006-7-19
pubmed:meshHeading
pubmed:articleTitle
Immunotoxic effects of TCDD and toxic equivalency factors.
pubmed:affiliation
Laboratory for Pathology and Immunobiology, National Institute of Public Health and the Environment, Bilthoven, The Netherlands.
pubmed:publicationType
Journal Article