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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
|
| pubmed:dateCreated |
1998-6-16
|
| pubmed:databankReference | |
| pubmed:abstractText |
Basic-helix-loop-helix (bHLH) proteins are transcriptional regulatory proteins that govern cell fate determination and differentiation in a variety of tissues. We have identified a novel bHLH protein, named Pod-1, that belongs to a recently-described subfamily of bHLH proteins that have essential roles in the embryonic development of mesodermal tissues. In the adult human and mouse, Pod-1 was most highly expressed in the kidney, lung and heart. In developing mouse embryos, Pod-1 was selectively expressed in mesenchymal cells at sites of epithelial-mesenchymal interaction in the kidney, lung, intestine and pancreas. Pod-1 was also expressed in visceral glomerular epithelial cells (podocytes) in the kidney, and its expression coincided with the onset of podocyte differentiation. The expression of Pod-1 in embryonic kidney explants was inhibited using antisense oligonucleotides. Inhibition of Pod-1 expression resulted in decreased mesenchymal cell condensation around the ureteric bud and a 40% decrease in ureteric branching. Pod-1 is the first tissue-restricted basic-helix-loop-helix protein that has been identified in the developing kidney where it may play a role in the regulation of morphogenetic events.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Basic Helix-Loop-Helix...,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/Oligonucleotides, Antisense,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0925-4773
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
71
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
37-48
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:9507058-Amino Acid Sequence,
pubmed-meshheading:9507058-Animals,
pubmed-meshheading:9507058-Basic Helix-Loop-Helix Transcription Factors,
pubmed-meshheading:9507058-Blotting, Northern,
pubmed-meshheading:9507058-Chromosome Mapping,
pubmed-meshheading:9507058-DNA, Complementary,
pubmed-meshheading:9507058-Epithelial Cells,
pubmed-meshheading:9507058-Female,
pubmed-meshheading:9507058-Helix-Loop-Helix Motifs,
pubmed-meshheading:9507058-Humans,
pubmed-meshheading:9507058-In Situ Hybridization,
pubmed-meshheading:9507058-Kidney Glomerulus,
pubmed-meshheading:9507058-Male,
pubmed-meshheading:9507058-Mesoderm,
pubmed-meshheading:9507058-Mice,
pubmed-meshheading:9507058-Mice, Inbred C57BL,
pubmed-meshheading:9507058-Mice, Inbred Strains,
pubmed-meshheading:9507058-Molecular Sequence Data,
pubmed-meshheading:9507058-Oligonucleotides, Antisense,
pubmed-meshheading:9507058-Organ Culture Techniques,
pubmed-meshheading:9507058-Organ Specificity,
pubmed-meshheading:9507058-Transcription Factors
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Pod-1, a mesoderm-specific basic-helix-loop-helix protein expressed in mesenchymal and glomerular epithelial cells in the developing kidney.
|
| pubmed:affiliation |
Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520-8029, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|