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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1998-5-28
|
| pubmed:abstractText |
Encasings for mattresses, blankets and pillows in combination with mite allergen reduction on the floor have proved effective in reducing bronchial hyperreactivity of mite-allergic children. We studied the effect of combining the use of encasings with specific immunotherapy in comparison to the use of encasings alone (control group). Twenty mite-allergic children (Skin Prick Test, RAST, mean age 10 years) with asthma and high domestic mite allergen exposure ( > 2 microg Der p 1 + f 1/g mattress dust) were included in our study. The concentration of these major allergens as well as specific and nonspecific bronchial hyperreactivity (PC20 FEV1 histamine) were assessed before, 6 months after and 1 year after start of treatment. All children received elongated polytetrafluorethylene (ePTFE; Goretex/Intervent Allergy Bedding System) encasings. A subgroup of eight children were treated additionally by specific immunotherapy with a partially purified mite extract (ALK Scherax) and a maximum dose of 100000 SQ-U Der p + f. Initially both groups were comparable with respect to the parameters assessed. In 80% of children, encasings reduced Der p 1 and Der f 1 concentrations on the mattress to below 3% of the initial values (P < 0.01). The median reduction was 99%. PC20 FEV1 histamine increased from 0.4 to 1.4 mg/dl (median) in the combined group with immunotherapy and encasings (P < 0.05) and remained essentially unchanged in the control group. PC20 FEV1 Der p did not increase significantly in either group. CONCLUSION: Specific immunotherapy with allergen extracts is an effective adjunct to encasings. Encasings, a key factor for reducing Der p 1 and Der f 1 on the mattress, should be used in combination with other avoidance measures (e.g. removal of carpets) in order to improve allergen-induced bronchial hyperreactivity.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0340-6199
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
157
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
109-13
|
| pubmed:dateRevised |
2006-4-19
|
| pubmed:meshHeading |
pubmed-meshheading:9504783-Adolescent,
pubmed-meshheading:9504783-Animals,
pubmed-meshheading:9504783-Asthma,
pubmed-meshheading:9504783-Bedding and Linens,
pubmed-meshheading:9504783-Bronchial Hyperreactivity,
pubmed-meshheading:9504783-Bronchial Provocation Tests,
pubmed-meshheading:9504783-Child,
pubmed-meshheading:9504783-Dust,
pubmed-meshheading:9504783-Environmental Exposure,
pubmed-meshheading:9504783-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:9504783-Female,
pubmed-meshheading:9504783-Histamine,
pubmed-meshheading:9504783-Humans,
pubmed-meshheading:9504783-Hypersensitivity,
pubmed-meshheading:9504783-Immunotherapy,
pubmed-meshheading:9504783-Male,
pubmed-meshheading:9504783-Mites,
pubmed-meshheading:9504783-Polytetrafluoroethylene,
pubmed-meshheading:9504783-Statistics, Nonparametric
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
The combined influence of immunotherapy and mite allergen reduction on bronchial hyperresponsiveness in mite-sensitive asthmatic children.
|
| pubmed:affiliation |
Virchow-Klinikum, Medizinische Fakultät der Humboldt-Universität zu Berlin, Pädiatrie m.S. Pneumologie/Immunologie, Germany.
|
| pubmed:publicationType |
Journal Article
|