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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1998-4-10
|
| pubmed:abstractText |
Nine cases of salivary duct carcinoma were reviewed clinically, histologically and immunohistochemically, with special evaluation of biomarkers with prognostic significance (p53, Ki67, c-erbB-2 and DNA content). Eight tumours occurred in the parotid gland and one in the submandibular gland. The average age of the patients (8 males and 1 female) was 62.8 years (range = 47-74 years). Tumour size ranged from 1 to 6 cm (mean = 3.46 cm). Recurrences were found in 33.3% (3 patients), regional metastases in 44.4% (4 patients) and systemic metastases in 33.3% (3 patients). Three patients died of their disease (median survival = 12.3 months), one is alive with the disease (follow-up of 222 months) and 5 are alive without evidence of disease (mean follow-up of 75 months). p53 protein nuclear immunostaining was positive in 66.6% and c-erbB-2 overexpression was observed in 100% of the tumours. Ki 67 positivity ranged from 6.75% to 47.5% of tumour cells (mean = 21.3%). DNA aneuploidy was found in 4 tumours (44.4%) and DNA diploidy in 5 (55.5%). Our results seem to indicate that Ki67 immunostaining can be useful in the evaluation of the biological behaviour of these tumours, as well as the presence of a high proliferative index of aneuploid cells and the presence of distant metastases.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
D
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Ki-67 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, erbB-2,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p53
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
1010-5182
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
25
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
328-34
|
| pubmed:dateRevised |
2009-11-19
|
| pubmed:meshHeading |
pubmed-meshheading:9504310-Aged,
pubmed-meshheading:9504310-Aneuploidy,
pubmed-meshheading:9504310-Antigens, Neoplasm,
pubmed-meshheading:9504310-Carcinoma,
pubmed-meshheading:9504310-Female,
pubmed-meshheading:9504310-Flow Cytometry,
pubmed-meshheading:9504310-Humans,
pubmed-meshheading:9504310-Ki-67 Antigen,
pubmed-meshheading:9504310-Lymphatic Metastasis,
pubmed-meshheading:9504310-Male,
pubmed-meshheading:9504310-Middle Aged,
pubmed-meshheading:9504310-Neoplasm Recurrence, Local,
pubmed-meshheading:9504310-Parotid Neoplasms,
pubmed-meshheading:9504310-Receptor, erbB-2,
pubmed-meshheading:9504310-Salivary Ducts,
pubmed-meshheading:9504310-Submandibular Gland Neoplasms,
pubmed-meshheading:9504310-Tumor Markers, Biological,
pubmed-meshheading:9504310-Tumor Suppressor Protein p53
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Salivary duct carcinoma: clinicopathological and immunohistochemical studies.
|
| pubmed:affiliation |
Pathology Service, Virgen de la Arrixaca University Hospital, El Palmar, Murcia, Spain.
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| pubmed:publicationType |
Journal Article
|