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rdf:type |
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lifeskim:mentions |
|
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pubmed:issue |
1
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pubmed:dateCreated |
1998-4-28
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pubmed:abstractText |
Amyloid beta protein 1-40 (A beta40) and A beta42 levels were quantitated in plasma from 43 persons with Down syndrome (DS; 26-68 years of age), 43 age-matched normal controls, and 19 non-DS mentally retarded (MR) persons (26-91 years of age) by using a sandwich enzyme linked immunosorbent assay. A beta40 levels were higher in DS and MR than controls, but were similar between DS and MR groups. A beta42 levels were higher in DS than controls or MR persons. The ratios of A beta42/A beta40 were higher in DS than controls or MR persons. The findings are consistent with those seen in DS brains.
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pubmed:grant |
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Jan
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|
pubmed:issn |
0304-3940
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
23
|
|
pubmed:volume |
241
|
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
13-6
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:9502204-Adult,
pubmed-meshheading:9502204-Aged,
pubmed-meshheading:9502204-Aged, 80 and over,
pubmed-meshheading:9502204-Amyloid beta-Peptides,
pubmed-meshheading:9502204-Down Syndrome,
pubmed-meshheading:9502204-Female,
pubmed-meshheading:9502204-Gene Dosage,
pubmed-meshheading:9502204-Humans,
pubmed-meshheading:9502204-Intellectual Disability,
pubmed-meshheading:9502204-Male,
pubmed-meshheading:9502204-Middle Aged,
pubmed-meshheading:9502204-Peptide Fragments,
pubmed-meshheading:9502204-Trisomy
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|
pubmed:year |
1998
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|
pubmed:articleTitle |
Increased plasma amyloid beta protein 1-42 levels in Down syndrome.
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|
pubmed:affiliation |
Department of Immunology, New York State Institute for Basic Research, Staten Island 10314-6399, USA. pdmehta@worldnet.att.net
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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