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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1998-4-28
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pubmed:abstractText |
Elevated total plasma homocysteine levels are associated with an increased risk of coronary artery disease. Plasma homocysteine levels are influenced by nutritional and hereditary factors. A point mutation (cytosin to thymidine substitution; C677-->T) in the gene encoding methylenetetrahydrofolate reductase (MTHFR), has been reported to render the enzyme thermolabile and has been associated with elevations in homocysteine levels in homozygous carriers (TT genotype).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0014-2972
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
20-3
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9502183-Adult,
pubmed-meshheading:9502183-Aged,
pubmed-meshheading:9502183-Case-Control Studies,
pubmed-meshheading:9502183-Coronary Disease,
pubmed-meshheading:9502183-Female,
pubmed-meshheading:9502183-Gene Frequency,
pubmed-meshheading:9502183-Genotype,
pubmed-meshheading:9502183-Germany,
pubmed-meshheading:9502183-Humans,
pubmed-meshheading:9502183-Male,
pubmed-meshheading:9502183-Methylenetetrahydrofolate Reductase (NADPH2),
pubmed-meshheading:9502183-Middle Aged,
pubmed-meshheading:9502183-Oxidoreductases Acting on CH-NH Group Donors,
pubmed-meshheading:9502183-Point Mutation,
pubmed-meshheading:9502183-Risk Factors
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pubmed:year |
1998
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pubmed:articleTitle |
Absence of association between a common mutation in the methylenetetrahydrofolate reductase gene and the risk of coronary artery disease.
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pubmed:affiliation |
Department of Internal Medicine, University of Jena, Germany. DREI@polkim.med.uni-jena.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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