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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1998-4-10
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pubmed:abstractText |
Axin antagonizes the developmental effects of Wnt in vertebrates. We show here that Axin simultaneously binds two components of the Wnt pathway, beta-catenin and its negative regulator glycogen synthase kinase-3beta. In mammalian cells, Axin inhibits Wnt-1 stimulation of beta-catenin/lymphoid enhancer factor 1-dependent transcription. Axin also blocks beta-catenin-mediated transcription in colon cancer cells that have a mutation in the adenomatous polyposis coli gene. These findings suggest that Axin, by forming a complex with beta-catenin and glycogen synthase kinase-3beta, can block signaling stimulated by Wnt or by adenomatous polyposis coli mutations.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501208-1617723,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501208-1651562,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501208-1651563,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501208-2547163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501208-2582493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501208-2673541,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501208-3019559,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501208-3039373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501208-3105892,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501208-6318122,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501208-7715701,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501208-7876319,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501208-8149915,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501208-8385345,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501208-8638126,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501208-8666229,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501208-8756721,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501208-8757136,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501208-9065401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501208-9065402,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501208-9065403,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501208-9230313
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adenomatous Polyposis Coli Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Axin Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Calmodulin-Dependent...,
http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Glycogen Synthase Kinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Glycogen Synthase Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphoid Enhancer-Binding Factor 1,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt1 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Zebrafish Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/beta Catenin
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
17
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pubmed:volume |
95
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3020-3
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:9501208-Adenomatous Polyposis Coli Protein,
pubmed-meshheading:9501208-Axin Protein,
pubmed-meshheading:9501208-Calcium-Calmodulin-Dependent Protein Kinases,
pubmed-meshheading:9501208-Cytoskeletal Proteins,
pubmed-meshheading:9501208-DNA-Binding Proteins,
pubmed-meshheading:9501208-Gene Expression Regulation,
pubmed-meshheading:9501208-Genes, Reporter,
pubmed-meshheading:9501208-Glycogen Synthase Kinase 3,
pubmed-meshheading:9501208-Glycogen Synthase Kinases,
pubmed-meshheading:9501208-Lymphoid Enhancer-Binding Factor 1,
pubmed-meshheading:9501208-Protein Binding,
pubmed-meshheading:9501208-Proteins,
pubmed-meshheading:9501208-Proto-Oncogene Proteins,
pubmed-meshheading:9501208-Repressor Proteins,
pubmed-meshheading:9501208-Signal Transduction,
pubmed-meshheading:9501208-Trans-Activators,
pubmed-meshheading:9501208-Transcription, Genetic,
pubmed-meshheading:9501208-Transcription Factors,
pubmed-meshheading:9501208-Wnt Proteins,
pubmed-meshheading:9501208-Wnt1 Protein,
pubmed-meshheading:9501208-Zebrafish Proteins,
pubmed-meshheading:9501208-beta Catenin
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pubmed:year |
1998
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pubmed:articleTitle |
Bridging of beta-catenin and glycogen synthase kinase-3beta by axin and inhibition of beta-catenin-mediated transcription.
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pubmed:affiliation |
Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143-0130, USA. chies@itsa.ucsf.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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