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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1998-4-3
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pubmed:databankReference |
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pubmed:abstractText |
To further investigate the molecular basis underlying the dysregulation of B cell homeostasis associated with bovine leukemia virus disease progression in cattle, bovine bax was cDNA cloned and sequenced. The predicted amino acid sequence of bovine Bax revealed a 192-amino-acid protein having extensive identity with the human (97%), murine (93%), and rat (94%) homologues. Because the ratio of Bcl-2 to Bax is believed to predetermine the susceptibility to a given apoptotic stimulus, the relative expression of the genes encoding these oncoproteins was evaluated in cattle naturally infected with BLV. In BLV-infected cattle an increase in the ratios of bcl-2/bax mRNA and protein expression correlated with advancing stages of disease. These findings suggest that in addition to the maintenance of BLV-associated hematopoietic malignancies, the reciprocal expression of Bcl-2/Bax may modulate the induction of B cell expansion typical of BLV disease progression.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0042-6822
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
242
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
184-92
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9501056-Amino Acid Sequence,
pubmed-meshheading:9501056-Animals,
pubmed-meshheading:9501056-Base Sequence,
pubmed-meshheading:9501056-Cattle,
pubmed-meshheading:9501056-Cloning, Molecular,
pubmed-meshheading:9501056-DNA Primers,
pubmed-meshheading:9501056-Enzootic Bovine Leukosis,
pubmed-meshheading:9501056-Female,
pubmed-meshheading:9501056-Humans,
pubmed-meshheading:9501056-Leukemia Virus, Bovine,
pubmed-meshheading:9501056-Molecular Sequence Data,
pubmed-meshheading:9501056-Oligonucleotide Probes,
pubmed-meshheading:9501056-Proto-Oncogene Proteins,
pubmed-meshheading:9501056-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:9501056-Rats,
pubmed-meshheading:9501056-Recombinant Proteins,
pubmed-meshheading:9501056-Sequence Alignment,
pubmed-meshheading:9501056-Sequence Homology, Amino Acid,
pubmed-meshheading:9501056-bcl-2-Associated X Protein
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pubmed:year |
1998
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pubmed:articleTitle |
Increased ratio of bcl-2/bax expression is associated with bovine leukemia virus-induced leukemogenesis in cattle.
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pubmed:affiliation |
Department of Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins 80523-1671, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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