Linked Life Data

9500490

Source:http://linkedlifedata.com/resource/pubmed/id/9500490

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1998-3-19
pubmed:abstractText
This open-label, two-period, crossover study was conducted to evaluate the effect of a single 150 mg dose of fluconazole on the pharmacokinetics of ethinyl estradiol in healthy female subjects.
pubmed:keyword
http://linkedlifedata.com/resource/pubmed/keyword/Clinical Research, http://linkedlifedata.com/resource/pubmed/keyword/Contraception, http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents..., http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents..., http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive..., http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Methods, http://linkedlifedata.com/resource/pubmed/keyword/DRUGS, http://linkedlifedata.com/resource/pubmed/keyword/Drug Interactions, http://linkedlifedata.com/resource/pubmed/keyword/Ethinyl Estradiol--pharmacodynamics, http://linkedlifedata.com/resource/pubmed/keyword/Family Planning, http://linkedlifedata.com/resource/pubmed/keyword/Oral Contraceptives, http://linkedlifedata.com/resource/pubmed/keyword/Oral Contraceptives, Combined, http://linkedlifedata.com/resource/pubmed/keyword/Research Methodology, http://linkedlifedata.com/resource/pubmed/keyword/Research Report, http://linkedlifedata.com/resource/pubmed/keyword/Treatment
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0002-9378
pubmed:author
pubmed:issnType
Print
pubmed:volume
178
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
300-4
pubmed:dateRevised
2006-11-15
pubmed:otherAbstract
PIP: The effect of a single dose of the imidazole antifungal agent fluconazole on circulating ethinyl estradiol levels in oral contraceptive (OC) users was investigated in an open-label, two-period, crossover study. 10 regular users of Ortho-Novum 7/7/7 and 10 women regularly taking Triphasil were randomly assigned to receive 150 mg of fluconazole 2 hours before OC ingestion on pill day 6 of one of two menstrual cycles. Mean serum concentrations of ethinyl estradiol were increased after fluconazole administration in both OC groups. Maximum observed serum concentration and area under the concentration time curve values were significantly greater during the fluconazole cycle for both OC groups and for the combined values of the two groups (p 0.05). The mean time to reach the maximum concentration was not altered by concomitant fluconazole administration. Mean serum ethinyl estradiol concentrations were greater at all time points in Ortho-Novum 7/7/7 users than Triphasil users. These findings suggest there is potential for a clinically significant drug interaction between co-administration of fluconazole and ethinyl estradiol. The most likely site of this drug interaction is the hepatic cytochrome P450 enzyme system. Since a single dose of 150 mg of fluconazole is standard treatment for common vaginal yeast infections, such concomitant therapy is likely in OC users at some point and its implications should be considered by prescribing clinicians.
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
The effect of fluconazole on circulating ethinyl estradiol levels in women taking oral contraceptives.
pubmed:affiliation
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick 08901-1977, USA.
pubmed:publicationType
Journal Article, Clinical Trial, Randomized Controlled Trial, Research Support, Non-U.S. Gov't