Linked Life Data

9499238

Source:http://linkedlifedata.com/resource/pubmed/id/9499238

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1998-3-12
pubmed:abstractText
Hepatitis C virus (HCV) circulating in patient's blood acquired cytopathogenic properties after infection of suckling mouse brain cells. HCV infection of PS cells was studied for 11 months. Three stages of infection were distinguished; noncytocidal infection, poorly manifest destruction of PS cells, and intensive cytodestruction and cell repopulation. Persistent HCV was steadily released in PS culture and caused destruction of BHK-21, Vero, PS, HAK, and chick embryo cells. Infective titers of HCV in culture fluid collected from these cultures were 10.0 = 11.0 lg TCD50/0.2 ml. Cytopathogenic activity of HCV regularly confirmed by the polymerase chain reaction was neutralized by anti-HCV-positive sera of patients with hepatitis C. Persistent HCV formed heterogeneous plaques in chick embryo fibroblast cultures and agglutinated goose erythrocytes. Indirect immunofluorescence demonstrated that 25 to 45% of infected cells contained virus-specific antigens. The PS-HCV system holds the best promise for theoretical and practical studies of hepatitis C.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0507-4088
pubmed:author
pubmed:issnType
Print
pubmed:volume
42
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
259-63
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:articleTitle
[Chronic infection of swine embryonal kidney cells (PS), caused by hepatitis C virus].
pubmed:publicationType
Journal Article, English Abstract