| pubmed-article:9498744 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9498744 | lifeskim:mentions | umls-concept:C0011616 | lld:lifeskim |
| pubmed-article:9498744 | lifeskim:mentions | umls-concept:C0123759 | lld:lifeskim |
| pubmed-article:9498744 | lifeskim:mentions | umls-concept:C2698599 | lld:lifeskim |
| pubmed-article:9498744 | lifeskim:mentions | umls-concept:C0567416 | lld:lifeskim |
| pubmed-article:9498744 | lifeskim:mentions | umls-concept:C0104998 | lld:lifeskim |
| pubmed-article:9498744 | lifeskim:mentions | umls-concept:C1704410 | lld:lifeskim |
| pubmed-article:9498744 | lifeskim:mentions | umls-concept:C1413243 | lld:lifeskim |
| pubmed-article:9498744 | lifeskim:mentions | umls-concept:C1366561 | lld:lifeskim |
| pubmed-article:9498744 | lifeskim:mentions | umls-concept:C1705431 | lld:lifeskim |
| pubmed-article:9498744 | lifeskim:mentions | umls-concept:C1555029 | lld:lifeskim |
| pubmed-article:9498744 | lifeskim:mentions | umls-concept:C0443211 | lld:lifeskim |
| pubmed-article:9498744 | lifeskim:mentions | umls-concept:C0392760 | lld:lifeskim |
| pubmed-article:9498744 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:9498744 | pubmed:dateCreated | 1998-3-18 | lld:pubmed |
| pubmed-article:9498744 | pubmed:abstractText | Cutaneous painting with reactive haptens induces contact sensitivity (CS) responses that are in vivo examples of T cell immunity. In contrast, high dose i.v. administration of the hapten can induce tolerance. We investigated the effect of IL-12 on reversal of this tolerance and attempted to determine in vitro the mechanism of this reversing effect by measuring proliferation and IFN-gamma production by CS effector T cells stimulated with hapten-conjugated APC, and we also measured CS ear swelling in vivo. The in vitro responses of T cells to hapten-APC became absent in tolerized mice, paralleling impaired in vivo CS responses. Addition of IL-12 to cultures manifesting this fully established in vitro tolerance completely restored impaired responses of tolerized T cells. The reversing effects of IL-12 were not blocked by anti-IFN-gamma mAb, but were blocked by mAbs against B7-1, more strongly by anti-B7-2, and by both Abs together. Additional in vivo ear-swelling response experiments confirmed the reversing effects of IL-12 on established tolerance. To examine whether the IL-12 effect depended on stimulation of IFN-gamma, we directly injected IFN-gamma into tolerized mice. This partially mimicked but did not fully reconstitute the effects of IL-12. In summary, IL-12 abrogation of established tolerance of CS may have been partially due to endogenous production of IFN-gamma, but appeared mainly due to direct activation of the tolerized T cells by affecting signaling through costimulatory molecules B7-1 and B7-2. | lld:pubmed |
| pubmed-article:9498744 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9498744 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9498744 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9498744 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9498744 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9498744 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:9498744 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9498744 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9498744 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9498744 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9498744 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9498744 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9498744 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9498744 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9498744 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9498744 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:9498744 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:9498744 | pubmed:author | pubmed-author:MatsudaHH | lld:pubmed |
| pubmed-article:9498744 | pubmed:author | pubmed-author:AskenaseP WPW | lld:pubmed |
| pubmed-article:9498744 | pubmed:author | pubmed-author:KawamotoKK | lld:pubmed |
| pubmed-article:9498744 | pubmed:author | pubmed-author:UshioHH | lld:pubmed |
| pubmed-article:9498744 | pubmed:author | pubmed-author:SzczepanikMM | lld:pubmed |
| pubmed-article:9498744 | pubmed:author | pubmed-author:TsujiR FRF | lld:pubmed |
| pubmed-article:9498744 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9498744 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:9498744 | pubmed:volume | 160 | lld:pubmed |
| pubmed-article:9498744 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9498744 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9498744 | pubmed:pagination | 2080-8 | lld:pubmed |
| pubmed-article:9498744 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:9498744 | pubmed:meshHeading | pubmed-meshheading:9498744-... | lld:pubmed |
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| pubmed-article:9498744 | pubmed:meshHeading | pubmed-meshheading:9498744-... | lld:pubmed |
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| pubmed-article:9498744 | pubmed:meshHeading | pubmed-meshheading:9498744-... | lld:pubmed |
| pubmed-article:9498744 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9498744 | pubmed:articleTitle | IL-12 reverses established antigen-specific tolerance of contact sensitivity by affecting costimulatory molecules B7-1 (CD80) and B7-2 (CD86). | lld:pubmed |
| pubmed-article:9498744 | pubmed:affiliation | Department of Veterinary Surgery, University of Osaka Prefecture College of Agriculture, Japan. | lld:pubmed |
| pubmed-article:9498744 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9498744 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9498744 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9498744 | lld:pubmed |
