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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1998-4-27
|
| pubmed:abstractText |
Acetylcholine-induced vasodilatation is impaired in animal models of insulin-dependent diabetes mellitus (IDDM), and may result from altered nitric oxide synthesis or release. The response to intraluminal flow, a more physiologically relevant stimulus for nitric oxide release, is unknown. This study examined flow-induced responses in isolated resistance arteries from male Sprague-Dawley control and streptozotocin-diabetic (45 mg/kg i.v., 4 week duration) rats. Mesenteric arteries (4-5th order) were dissected and cannulated on a pressure myograph (mean internal diameter +/- SEM at 40 mmHg, control 223 +/- 8, n = 9 vs diabetic 239 +/- 12 microm, n = 8, NS). Arteries were preconstricted with noradrenaline (1 micromol/l) and intraluminal pressure raised and maintained at 80 mmHg. Luminal flow was raised in incremental steps (0-1.27 microl/s). Arteries from control animals dilated to flow while arteries from diabetic animals constricted (% change in internal diameter +/- SEM at 0.79 microl/s: control 13.46 +/- 6.52, n = 9 vs diabetic -7.44 +/- 3.38%, n = 8; p < 0.005). Incubation with N(omega)-nitro-L-arginine methyl ester (0.1 mmol/l) abolished flow responses in arteries from controls but not from diabetic rats. In conclusion, impaired flow-induced nitric oxide-mediated vasodilatation may contribute to vascular disease in IDDM.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0012-186X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
41
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
34-9
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9498627-Acetylcholine,
pubmed-meshheading:9498627-Animals,
pubmed-meshheading:9498627-Blood Flow Velocity,
pubmed-meshheading:9498627-Diabetes Mellitus, Experimental,
pubmed-meshheading:9498627-Intestine, Small,
pubmed-meshheading:9498627-Male,
pubmed-meshheading:9498627-Mesenteric Arteries,
pubmed-meshheading:9498627-Muscle, Smooth, Vascular,
pubmed-meshheading:9498627-NG-Nitroarginine Methyl Ester,
pubmed-meshheading:9498627-Norepinephrine,
pubmed-meshheading:9498627-Rats,
pubmed-meshheading:9498627-Rats, Sprague-Dawley,
pubmed-meshheading:9498627-Reference Values,
pubmed-meshheading:9498627-Stress, Mechanical,
pubmed-meshheading:9498627-Vasodilation
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Flow-induced dilatation in isolated resistance arteries from control and streptozotocin-diabetic rats.
|
| pubmed:affiliation |
Department of Obstetrics and Gynaecology, UMDS, St. Thomas' Hospital, London, UK.
|
| pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|