| pubmed-article:9498161 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9498161 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:9498161 | lifeskim:mentions | umls-concept:C0229671 | lld:lifeskim |
| pubmed-article:9498161 | lifeskim:mentions | umls-concept:C0033860 | lld:lifeskim |
| pubmed-article:9498161 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:9498161 | lifeskim:mentions | umls-concept:C0521117 | lld:lifeskim |
| pubmed-article:9498161 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:9498161 | lifeskim:mentions | umls-concept:C0392756 | lld:lifeskim |
| pubmed-article:9498161 | lifeskim:mentions | umls-concept:C1704419 | lld:lifeskim |
| pubmed-article:9498161 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:9498161 | pubmed:dateCreated | 1998-4-14 | lld:pubmed |
| pubmed-article:9498161 | pubmed:abstractText | TNF-alpha is a pleiotropic cytokine possibly involved in the pathogenesis of psoriasis. Objective: to analyze the serum TNF-alpha levels in plaque-type psoriatic patients to evaluate the concentrations, correlation with the severity score and behaviour after therapy. The serum TNF-alpha levels of thirty-seven patients (25 females and 12 males; median age: 52.5 years, range 18-81: median PASI score: 11.4, range 3.5-42) and thirty healthy controls (21 females and 9 males, median age: 48.5 years, range 25-77) were compared after measurements obtained employing commercially available ELISA kits. The median serum TNF-alpha levels of the patients were significantly higher than those of controls (p = 0.004). 30/37 patients were followed over time at 2 and 4 weeks of treatment. Twenty one subjects were also observed after 6 weeks. After effective treatments, both the PASI scores and the cytokine levels were significantly and concomitantly reduced (p < 0.001). Significant correlations were found when the TNF-alpha values were plotted against the PASI scores both at the time of patient enrollment and at all the subsequent times (118 observations). A significant correlation was observed between circulating TNF-alpha and sE-selectin in agreement with a possible functional activity of the cytokine. However, no correlation was found between the cytokine levels and other 4 soluble membrane molecules. Our findings indicate that the molecule studied, although non specific for the disease considered, presents a behaviour paralleling that of the disease severity and therefore might have clinical usefulness, particularly in monitoring the therapeutic effects. | lld:pubmed |
| pubmed-article:9498161 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9498161 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9498161 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9498161 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9498161 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9498161 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9498161 | pubmed:issn | 0393-974X | lld:pubmed |
| pubmed-article:9498161 | pubmed:author | pubmed-author:FazioMM | lld:pubmed |
| pubmed-article:9498161 | pubmed:author | pubmed-author:AmeglioFF | lld:pubmed |
| pubmed-article:9498161 | pubmed:author | pubmed-author:MussoGG | lld:pubmed |
| pubmed-article:9498161 | pubmed:author | pubmed-author:D'UrsoDD | lld:pubmed |
| pubmed-article:9498161 | pubmed:author | pubmed-author:PimpinelliFF | lld:pubmed |
| pubmed-article:9498161 | pubmed:author | pubmed-author:CarducciMM | lld:pubmed |
| pubmed-article:9498161 | pubmed:author | pubmed-author:BonifatiCC | lld:pubmed |
| pubmed-article:9498161 | pubmed:author | pubmed-author:D'AuriaLL | lld:pubmed |
| pubmed-article:9498161 | pubmed:author | pubmed-author:D'AgostoGG | lld:pubmed |
| pubmed-article:9498161 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9498161 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:9498161 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9498161 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9498161 | pubmed:pagination | 115-8 | lld:pubmed |
| pubmed-article:9498161 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
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| pubmed-article:9498161 | pubmed:articleTitle | Serum TNF-alpha levels correlate with disease severity and are reduced by effective therapy in plaque-type psoriasis. | lld:pubmed |
| pubmed-article:9498161 | pubmed:affiliation | Laboratory of Clinical Pathology, S.Gallicano Institute, Roma, Italy. | lld:pubmed |
| pubmed-article:9498161 | pubmed:publicationType | Journal Article | lld:pubmed |
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