Linked Life Data

9498152

Source:http://linkedlifedata.com/resource/pubmed/id/9498152

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1998-5-5
pubmed:abstractText
Plaster of Paris implants containing vancomycin (60 mg/g of carrier) were prepared in order to be used as local delivery system for the treatment of bone infections. The regulation of the release rate was performed by coating the carrier with a polylactide-co-glycolide polymer composed by 10% (w/w) polyglycolic acid and 90% (w/w) racemic poly (D,L-lactic acid). The release of the antibiotic from the biodegradable matrix was evaluated in vitro. From this investigation, it is clear that the drug elution depends on the coating depth. After a burst effect occurring on the first day of the experiment, therapeutic concentrations were measured during one week when uncoated implants were used. The coating allowed decrease of the burst effect and extended efficient release to more than five weeks when the implants were embedded with six layers (162 microns) of PLA45GA10. This delivery system was implanted into the femoral condyle of rabbits. It was shown that the in vivo release was also closely regulated by the coating depth. In all bone tissues (bone marrow and cortical bone) surrounding the pellets, the drug concentration exceeded the Minimum Inhibitory Concentration for the common causative organisms of bone infections (Staphylococcus aureus) for at least four weeks without inducing serum toxic levels. Due to its cheapness, facility of use and sterilization, biocompatibility and biodegradability, plaster of Paris coated with PLA45GA10 polymer giving a controlled release of vancomycin appears to be a promising sustained release delivery system of antibiotics for the treatment of bone and joint infections.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0341-2695
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
403-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:9498152-Animals, pubmed-meshheading:9498152-Anti-Bacterial Agents, pubmed-meshheading:9498152-Biocompatible Materials, pubmed-meshheading:9498152-Biodegradation, Environmental, pubmed-meshheading:9498152-Calcium Sulfate, pubmed-meshheading:9498152-Delayed-Action Preparations, pubmed-meshheading:9498152-Disease Models, Animal, pubmed-meshheading:9498152-Drug Delivery Systems, pubmed-meshheading:9498152-Drug Implants, pubmed-meshheading:9498152-Femur, pubmed-meshheading:9498152-Fluorescence Polarization Immunoassay, pubmed-meshheading:9498152-Lactic Acid, pubmed-meshheading:9498152-Materials Testing, pubmed-meshheading:9498152-Osteomyelitis, pubmed-meshheading:9498152-Polyglycolic Acid, pubmed-meshheading:9498152-Polymers, pubmed-meshheading:9498152-Rabbits, pubmed-meshheading:9498152-Staphylococcal Infections, pubmed-meshheading:9498152-Vancomycin
pubmed:year
1997
pubmed:articleTitle
Antibiotic-loaded plaster of Paris implants coated with poly lactide-co-glycolide as a controlled release delivery system for the treatment of bone infections.
pubmed:affiliation
Louvain Catholic University, Brussels, Belgium.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't