|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
12
|
|
pubmed:dateCreated |
1998-3-17
|
|
pubmed:databankReference |
|
|
pubmed:abstractText |
The secretion pattern of putuitary growth hormone (GH) in rodents is sexually dimorphic and regulates the expression of some hepatic genes. We report cloning of mouse glycine N-methyltransferase (GNMT) cDNA. The mouse GNMT mRNA is expressed at much lower levels in male than in female livers. Hypophysectomy in male mice resulted in as a high level of the expression as in female mice. Treatment with GH of hypophysectomized male mice twice a day for 5 days decreased the expression. These results indicate that the sex difference of the mouse GNMT expression is regulated by GH secretion patterns.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0018-5043
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
29
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
646-9
|
|
pubmed:dateRevised |
2009-2-19
|
|
pubmed:meshHeading |
pubmed-meshheading:9497905-Amino Acid Sequence,
pubmed-meshheading:9497905-Animals,
pubmed-meshheading:9497905-Base Sequence,
pubmed-meshheading:9497905-Cloning, Molecular,
pubmed-meshheading:9497905-DNA, Complementary,
pubmed-meshheading:9497905-Female,
pubmed-meshheading:9497905-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:9497905-Glycine N-Methyltransferase,
pubmed-meshheading:9497905-Growth Hormone,
pubmed-meshheading:9497905-Liver,
pubmed-meshheading:9497905-Male,
pubmed-meshheading:9497905-Methyltransferases,
pubmed-meshheading:9497905-Mice,
pubmed-meshheading:9497905-Mice, Inbred BALB C,
pubmed-meshheading:9497905-Mice, Inbred DBA,
pubmed-meshheading:9497905-Molecular Sequence Data,
pubmed-meshheading:9497905-RNA, Messenger,
pubmed-meshheading:9497905-Sex Characteristics
|
|
pubmed:year |
1997
|
|
pubmed:articleTitle |
Mouse glycine N-methyltransferase is sexually dimorphic and regulated by growth hormone.
|
|
pubmed:affiliation |
Third Department of Internal Medicine, Yamanashi Medical University, Japan.
|
|
pubmed:publicationType |
Journal Article
|
