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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1998-3-30
|
| pubmed:abstractText |
This study evaluated the effects of combining antibiotic therapy with the application of a nonsteroidal anti-inflammatory drug on the degradation of articular cartilage for an animal model of Staphylococcal septic arthritis. Rabbits were infected intra-articularly with Staphylococcus aureus. Antibiotic treatment started 18 hours after infection and continued for 7 days. Treatment with the nonsteroidal anti-inflammatory drug naproxen sodium started 24 hours before infection and continued for either 3 or 7 weeks. The cartilage matrix of uninfected and infected knees was quantified by analysis of glycosaminoglycan and collagen content. Three weeks after infection, the combined treatment of the nonsteroidal anti-inflammatory drug and antibiotics reduced the loss of glycosaminoglycan and collagen from the cartilage of the infected knee by 15 and 30%, respectively, compared with antibiotic treatment alone. Continuing treatment with naproxen sodium for 7 weeks reduced the loss of collagen by 50% when compared with antibiotic treatment alone. The longer period of treatment with naproxen sodium showed little further effect on the loss of glycosaminoglycan than that observed for the 3-week treatment. Treatment with this drug and antibiotics reduced swelling of the knee and levels of prostaglandin E2 in the synovial fluid. The data support the hypothesis that decreasing post-infectious inflammation by adding the drug to a standard antibiotic regimen reduces cartilage damage from Staphylococcal septic arthritis.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents...,
http://linkedlifedata.com/resource/pubmed/chemical/Ceftriaxone,
http://linkedlifedata.com/resource/pubmed/chemical/Cephalosporins,
http://linkedlifedata.com/resource/pubmed/chemical/Dinoprostone,
http://linkedlifedata.com/resource/pubmed/chemical/Glycosaminoglycans,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxyproline,
http://linkedlifedata.com/resource/pubmed/chemical/Naproxen
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0736-0266
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
15
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
919-26
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:9497819-Animals,
pubmed-meshheading:9497819-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:9497819-Arthritis, Infectious,
pubmed-meshheading:9497819-Cartilage, Articular,
pubmed-meshheading:9497819-Ceftriaxone,
pubmed-meshheading:9497819-Cephalosporins,
pubmed-meshheading:9497819-Dinoprostone,
pubmed-meshheading:9497819-Disease Models, Animal,
pubmed-meshheading:9497819-Drug Therapy, Combination,
pubmed-meshheading:9497819-Female,
pubmed-meshheading:9497819-Glycosaminoglycans,
pubmed-meshheading:9497819-Hydroxyproline,
pubmed-meshheading:9497819-Knee Joint,
pubmed-meshheading:9497819-Naproxen,
pubmed-meshheading:9497819-Rabbits,
pubmed-meshheading:9497819-Staphylococcal Infections,
pubmed-meshheading:9497819-Staphylococcus aureus,
pubmed-meshheading:9497819-Synovial Fluid,
pubmed-meshheading:9497819-Synovitis
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Staphylococcal septic arthritis: antibiotic and nonsteroidal anti-inflammatory drug treatment in a rabbit model.
|
| pubmed:affiliation |
Orthopaedic Research Laboratory, Stanford University Medical Center, CA 94305-5341, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|