Linked Life Data

9496893

Source:http://linkedlifedata.com/resource/pubmed/id/9496893

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1998-3-18
pubmed:abstractText
We investigated the effect of hyperthermia at 40.5-42.5 degrees C as well as the combination of hyperthermia and carbogen breathing on oxygenation in the SCK murine mammary carcinoma. In addition, the important question of how long the effect of heating on tumor oxygenation lasts was addressed in both SCK and FSaII (murine fibrosarcoma) tumors. The median pO2 in control SCK tumors was 4.4 +/- 0.2 mm Hg, and it increased to a maximum of 12.6 +/- 1.2 mm Hg when the tumors were heated at 41.5 degrees C for 1 h. Carbogen breathing increased the median pO2 of SCK tumors to 17.1 +/- 1.4 mm Hg, but after heating at 41.5 degrees C, it elevated the pO2 in SCK tumors markedly to 31.3 +/- 4.2 mm Hg. The kinetics of the return to baseline oxygenation after hyperthermia was found to vary with the type of tumor and the heat dose. The pO2 of FSaII tumors remained significantly higher than that of control tumors 24 h after heating at 41.5 degrees C for 60 min. The pO2 of SCK tumors remained elevated for up to 3 h after heating at 41.5 degrees C for 30 min, but if the tumors were heated for 60 min at this temperature, the median oxygen tension declined to the control level within 1 h after heating. It was concluded that mild-temperature hyperthermia, i.e. 41.5 degrees C, alone and in combination with carbogen breathing dramatically improves the oxygenation of these murine tumors and that the tumor type influences the duration of changes in oxygenation induced by mild-temperature hyperthermia.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0033-7587
pubmed:author
pubmed:issnType
Print
pubmed:volume
149
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
294-9
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Tumor oxygenation after mild-temperature hyperthermia in combination with carbogen breathing: dependence on heat dose and tumor type.
pubmed:affiliation
University of Minnesota Medical School, Department of Therapeutic Radiology, Minneapolis 55455, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.