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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1998-4-16
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pubmed:abstractText |
Eukaryotic initiation factor 5A (elF-5A) contains an unusual amino acid, hypusine [N epsilon-(4-aminobutyl-2-hydroxy)lysine]. The first step in the post-translational formation of hypusine is catalysed by the enzyme deoxyhypusine synthase (DHS). The modified version of elF-5A, and DHS, are required for eukaryotic cell proliferation. Knowledge of the three-dimensional structure of this key enzyme should permit the design of specific inhibitors that may be useful as anti-proliferative agents.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0969-2126
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
23-32
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pubmed:dateRevised |
2005-12-29
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pubmed:meshHeading |
pubmed-meshheading:9493264-Binding Sites,
pubmed-meshheading:9493264-Crystallography, X-Ray,
pubmed-meshheading:9493264-Humans,
pubmed-meshheading:9493264-Hydrogen Bonding,
pubmed-meshheading:9493264-Lysine,
pubmed-meshheading:9493264-Models, Molecular,
pubmed-meshheading:9493264-NAD,
pubmed-meshheading:9493264-Oxidoreductases Acting on CH-NH Group Donors,
pubmed-meshheading:9493264-Peptide Initiation Factors,
pubmed-meshheading:9493264-Protein Conformation,
pubmed-meshheading:9493264-Protein Processing, Post-Translational,
pubmed-meshheading:9493264-Protein Structure, Secondary,
pubmed-meshheading:9493264-Recombinant Proteins,
pubmed-meshheading:9493264-Spermidine
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pubmed:year |
1998
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pubmed:articleTitle |
Crystal structure of the NAD complex of human deoxyhypusine synthase: an enzyme with a ball-and-chain mechanism for blocking the active site.
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pubmed:affiliation |
Laboratory of Molecular Biology, NIDDK, NIH, Bethesda, MD 20892-0560, USA.
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pubmed:publicationType |
Journal Article
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