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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1998-3-11
|
| pubmed:abstractText |
Ifosfamide, Carboplatin and Etoposide (ICE) therapy was used to treat 4 patients, 2 with refractory osteosarcoma, and one each with relapsed brain tumor and newly diagnosed brain tumor. ICE therapy was administered in doses of Ifosfamide 1,800 mg/m2 x 5, Carboplatin 400 mg/m2 x 2 and Etoposide 100 mg/m2 x 5. A total of 30 courses were administered. Two cases of osteosarcoma had a stable disease (range, 3-9 months) and 2 cases of brain tumor had a complete response by magnetic resonance imaging. Moderate or severe toxicity evaluated on a per course basis included: neutropenia 83%, thrombocytopenia 93%, fever 30%, hepatotoxicity 3%, and hemorrhagic cystitis 3%. The median time to hematologic recovery was 20 days. ICE therapy is highly effective for the treatment of refractory or recurrent solid tumors with acceptable toxicity.
|
| pubmed:language |
jpn
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0385-0684
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
25
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
385-90
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9492832-Adolescent,
pubmed-meshheading:9492832-Adult,
pubmed-meshheading:9492832-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:9492832-Bone Neoplasms,
pubmed-meshheading:9492832-Brain Neoplasms,
pubmed-meshheading:9492832-Carboplatin,
pubmed-meshheading:9492832-Child,
pubmed-meshheading:9492832-Drug Administration Schedule,
pubmed-meshheading:9492832-Etoposide,
pubmed-meshheading:9492832-Female,
pubmed-meshheading:9492832-Fever,
pubmed-meshheading:9492832-Humans,
pubmed-meshheading:9492832-Ifosfamide,
pubmed-meshheading:9492832-Lung Neoplasms,
pubmed-meshheading:9492832-Male,
pubmed-meshheading:9492832-Neoplasm Recurrence, Local,
pubmed-meshheading:9492832-Neutropenia,
pubmed-meshheading:9492832-Osteosarcoma,
pubmed-meshheading:9492832-Pilot Projects,
pubmed-meshheading:9492832-Thrombocytopenia
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
[Pilot study of relapsed osteosarcoma and brain tumor with ifosfamide, carboplatin and etoposide (ICE therapy)].
|
| pubmed:affiliation |
Dept. of Pediatrics, Aichi Medical University.
|
| pubmed:publicationType |
Journal Article,
English Abstract
|