rdf:type |
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lifeskim:mentions |
|
pubmed:issue |
9102
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pubmed:dateCreated |
1998-3-19
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pubmed:abstractText |
Fetal cells can be found in the maternal circulation in most pregnancies. Fetal progenitor cells have been found to persist in the circulation of women many years after childbirth. We tested the hypothesis that microchimerism is involved in the pathogenesis of scleroderma. Scleroderma is of interest because of a strong female predilection, an increased incidence in the years after childbearing, and clinical similarities between scleroderma and chronic graft-versus-host disease after allogeneic bone-marrow transplantation. We also investigated whether HLA-compatibility of a child was associated with later development of scleroderma in the mother.
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pubmed:grant |
|
pubmed:commentsCorrections |
|
pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
AIM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
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pubmed:month |
Feb
|
pubmed:issn |
0140-6736
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
351
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pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
559-62
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9492775-Adolescent,
pubmed-meshheading:9492775-Adult,
pubmed-meshheading:9492775-Chimera,
pubmed-meshheading:9492775-DNA,
pubmed-meshheading:9492775-Female,
pubmed-meshheading:9492775-Fetus,
pubmed-meshheading:9492775-Graft vs Host Disease,
pubmed-meshheading:9492775-HLA Antigens,
pubmed-meshheading:9492775-Histocompatibility Testing,
pubmed-meshheading:9492775-Homozygote,
pubmed-meshheading:9492775-Humans,
pubmed-meshheading:9492775-Male,
pubmed-meshheading:9492775-Maternal-Fetal Exchange,
pubmed-meshheading:9492775-Middle Aged,
pubmed-meshheading:9492775-Polymerase Chain Reaction,
pubmed-meshheading:9492775-Pregnancy,
pubmed-meshheading:9492775-Scleroderma, Systemic,
pubmed-meshheading:9492775-Y Chromosome
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pubmed:year |
1998
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pubmed:articleTitle |
Microchimerism and HLA-compatible relationships of pregnancy in scleroderma.
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pubmed:affiliation |
Fred Hutchinson Cancer Research Center, Seattle, Washington 98104-2092, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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