| pubmed-article:9492149 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9492149 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:9492149 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:9492149 | lifeskim:mentions | umls-concept:C0549473 | lld:lifeskim |
| pubmed-article:9492149 | lifeskim:mentions | umls-concept:C0063695 | lld:lifeskim |
| pubmed-article:9492149 | lifeskim:mentions | umls-concept:C1518174 | lld:lifeskim |
| pubmed-article:9492149 | lifeskim:mentions | umls-concept:C0033634 | lld:lifeskim |
| pubmed-article:9492149 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:9492149 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:9492149 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:9492149 | pubmed:dateCreated | 1998-4-2 | lld:pubmed |
| pubmed-article:9492149 | pubmed:abstractText | Nonantigen specific adhesion systems lymphocyte function-associated antigen 1/intercellular adhesion molecule (LFA-1/ICAM-1) and cluster designation 2/lymphocyte function-associated antigen 3 (CD2/LFA-3) are considered a crucial step in immune-mediated cell-cell adhesion reactions. In particular, the LFA-1/ICAM-1 system is deeply involved in major histocompatibility system (MHC)-restricted and non-MHC-restricted cellular cytotoxicity of effector cells against cancer tissues. We have investigated in human thyroid carcinoma cell lines the role of the protein kinase C (PKC) pathway on ICAM-1 expression. Incubation with tissue plasminogen activator (TPA), an agonist of PKC, of two papillary (NPA and TPC-1) and one anaplastic (ARO) carcinoma cell lines induced an ICAM-1 upregulation of both protein and mRNA production. This phenomenon was dependent on RNA and protein synthesis and was inhibited by PKC antagonists such as staurosporine and H-7. A parallel increase in the soluble form of ICAM-1 followed the upregulation of cellular ICAM-1 levels induced by TPA. In conclusion, the PKC pathway is involved in the regulation of ICAM-1 expression in human thyroid carcinoma cell lines. Further studies are necessary to clarify the effects of the PKC pathway on the diffusion of thyroid tumors. | lld:pubmed |
| pubmed-article:9492149 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9492149 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9492149 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9492149 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9492149 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9492149 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9492149 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9492149 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9492149 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9492149 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9492149 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9492149 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:9492149 | pubmed:issn | 1050-7256 | lld:pubmed |
| pubmed-article:9492149 | pubmed:author | pubmed-author:RossiGG | lld:pubmed |
| pubmed-article:9492149 | pubmed:author | pubmed-author:FenziG FGF | lld:pubmed |
| pubmed-article:9492149 | pubmed:author | pubmed-author:BassoLL | lld:pubmed |
| pubmed-article:9492149 | pubmed:author | pubmed-author:FelicielloAA | lld:pubmed |
| pubmed-article:9492149 | pubmed:author | pubmed-author:AltomonteMM | lld:pubmed |
| pubmed-article:9492149 | pubmed:author | pubmed-author:AllevatoGG | lld:pubmed |
| pubmed-article:9492149 | pubmed:author | pubmed-author:De RiuSS | lld:pubmed |
| pubmed-article:9492149 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9492149 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:9492149 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9492149 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9492149 | pubmed:pagination | 23-8 | lld:pubmed |
| pubmed-article:9492149 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:9492149 | pubmed:meshHeading | pubmed-meshheading:9492149-... | lld:pubmed |
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| pubmed-article:9492149 | pubmed:meshHeading | pubmed-meshheading:9492149-... | lld:pubmed |
| pubmed-article:9492149 | pubmed:meshHeading | pubmed-meshheading:9492149-... | lld:pubmed |
| pubmed-article:9492149 | pubmed:meshHeading | pubmed-meshheading:9492149-... | lld:pubmed |
| pubmed-article:9492149 | pubmed:meshHeading | pubmed-meshheading:9492149-... | lld:pubmed |
| pubmed-article:9492149 | pubmed:meshHeading | pubmed-meshheading:9492149-... | lld:pubmed |
| pubmed-article:9492149 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9492149 | pubmed:articleTitle | Intercellular adhesion molecule-1 is upregulated via the protein kinase C pathway in human thyroid carcinoma cell lines. | lld:pubmed |
| pubmed-article:9492149 | pubmed:affiliation | Dipartimento di Endocrinologia ed Oncologia Molecolare e Clinica, Università degli Studi di Napoli "Federico II", Facoltà di Medicina e Chirurgia, Naples, Italy. | lld:pubmed |
| pubmed-article:9492149 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9492149 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9492149 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9492149 | lld:pubmed |
