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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1998-3-19
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pubmed:abstractText |
Anti-Sm and anti-ssDNA transgenic (Tg) mice were generated using the VH-D-JH rearrangement of an anti-Sm hybridoma of MRL/Mp-lpr/lpr origin. B cells of each specificity account for 15%-35% of the splenic repertoire, but no circulating anti-Sm or anti-ssDNA antibodies are detected. Most autoreactive cells exhibit an immature B cell phenotype and have short half-lives equivalent to those of non-Tg immature B cells. However, at least some anti-Sm B cells are functional, because immunization with murine snRNPs induces anti-Sm secretion. We propose that anti-Sm and anti-ssDNA are eliminated during the transition to mature B cells and that this late stage of tolerance induction is consequential to their spontaneous activation in murine lupus.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1074-7613
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
209-19
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:9492002-Animals,
pubmed-meshheading:9492002-Autoantigens,
pubmed-meshheading:9492002-B-Lymphocytes,
pubmed-meshheading:9492002-Bone Marrow,
pubmed-meshheading:9492002-Cell Differentiation,
pubmed-meshheading:9492002-DNA, Single-Stranded,
pubmed-meshheading:9492002-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:9492002-Fluorescent Antibody Technique,
pubmed-meshheading:9492002-Gene Rearrangement, B-Lymphocyte, Heavy Chain,
pubmed-meshheading:9492002-Hematopoietic Stem Cells,
pubmed-meshheading:9492002-Hybridomas,
pubmed-meshheading:9492002-Immune Tolerance,
pubmed-meshheading:9492002-Lupus Erythematosus, Systemic,
pubmed-meshheading:9492002-Lymphocyte Activation,
pubmed-meshheading:9492002-Mice,
pubmed-meshheading:9492002-Mice, Inbred MRL lpr,
pubmed-meshheading:9492002-Mice, Transgenic,
pubmed-meshheading:9492002-Ribonucleoproteins, Small Nuclear,
pubmed-meshheading:9492002-Spleen,
pubmed-meshheading:9492002-snRNP Core Proteins
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pubmed:year |
1998
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pubmed:articleTitle |
Autoreactive B cell regulation: peripheral induction of developmental arrest by lupus-associated autoantigens.
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pubmed:affiliation |
Department of Microbiology and Immunology, University of North Carolina, Chapel Hill 27599, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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