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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1998-3-26
|
| pubmed:abstractText |
Four known alkaloids, lycorine (1), 1,2-di-O-acetyllycorine (2), ambelline (3), and crinine (4) were isolated from the bulbs of Brunsvigia littoralis (Amaryllidaceae). 1H- and 13C-NMR spectra of 2 were completely assigned by means of 1D- and 2D-NMR techniques. The alkaloids (1-4) together with the synthesised 11-O-acetylambelline (3a) and 3-O-acetylcrinine (4a) were tested for antimalarial activity with two strains of cultured Plasmodium falciparum and for cytotoxicity with BL6 mouse melanoma cells. Structures 1 and 2 exhibited both antimalarial and cytotoxic activity.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0032-0943
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
64
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
91-3
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9491773-Alkaloids,
pubmed-meshheading:9491773-Animals,
pubmed-meshheading:9491773-Antimalarials,
pubmed-meshheading:9491773-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:9491773-Magnetic Resonance Spectroscopy,
pubmed-meshheading:9491773-Melanoma, Experimental,
pubmed-meshheading:9491773-Mice,
pubmed-meshheading:9491773-Molecular Structure,
pubmed-meshheading:9491773-Plants, Medicinal,
pubmed-meshheading:9491773-Tumor Cells, Cultured
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Cytotoxic and antimalarial alkaloids from Brunsvigia littoralis.
|
| pubmed:publicationType |
Letter,
Research Support, Non-U.S. Gov't
|