Linked Life Data

9490848

Source:http://linkedlifedata.com/resource/pubmed/id/9490848

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1998-4-2
pubmed:abstractText
1. The K+ currents of spinal neurons acutely dissociated from Xenopus larvae were studied and compared with those of neurons dissociated from Xenopus embryos. 2. The density of total outward current in the larval and embryonic neurons remained the same from stage 37/38 to stage 42. 3. Almost all neurons at stage 42 expressed a fast activating Ca2+-dependent K+ current (IKCa) that was largely absent from embryonic neurons. Whereas IKCa became larger and more prevalent during development, the delayed rectifier K+ currents were down-regulated. 4. About 53 % of IKCa was selectively blocked by iberiotoxin which had no effect on the delayed rectifier K+ currents or the K+ currents of embryonic neurons. 5. The firing properties of neurons isolated from embryos were unchanged by iberiotoxin. However, the toxin greatly increased the frequency of firing in larval neurons. 6. Iberiotoxin extended the duration of ventral root bursts during fictive swimming in larvae at stages 41 and 42 but had no effect at stage 40. The progressive expression of IKCa thus contributed to burst termination. 7. We have found that changes in expression of outward current closely correlate with the maturation of the motor pattern during development. At a time when the motor pattern has a need for a burst-terminating mechanism, the larval neurons express a channel with properties appropriate for such a role.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/9490848-1694175, http://linkedlifedata.com/resource/pubmed/commentcorrection/9490848-2442762, http://linkedlifedata.com/resource/pubmed/commentcorrection/9490848-2582265, http://linkedlifedata.com/resource/pubmed/commentcorrection/9490848-3346722, http://linkedlifedata.com/resource/pubmed/commentcorrection/9490848-7643212, http://linkedlifedata.com/resource/pubmed/commentcorrection/9490848-7823105, http://linkedlifedata.com/resource/pubmed/commentcorrection/9490848-7987297, http://linkedlifedata.com/resource/pubmed/commentcorrection/9490848-8027440, http://linkedlifedata.com/resource/pubmed/commentcorrection/9490848-8041498, http://linkedlifedata.com/resource/pubmed/commentcorrection/9490848-8173315, http://linkedlifedata.com/resource/pubmed/commentcorrection/9490848-8463824, http://linkedlifedata.com/resource/pubmed/commentcorrection/9490848-8544121, http://linkedlifedata.com/resource/pubmed/commentcorrection/9490848-8636469, http://linkedlifedata.com/resource/pubmed/commentcorrection/9490848-8847641, http://linkedlifedata.com/resource/pubmed/commentcorrection/9490848-8847642, http://linkedlifedata.com/resource/pubmed/commentcorrection/9490848-9218221
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0022-3751
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
507 ( Pt 1)
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
257-64
pubmed:dateRevised
2010-9-13
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Developmental changes in expression of ion currents accompany maturation of locomotor pattern in frog tadpoles.
pubmed:affiliation
School of Biomedical Sciences, Bute Medical Building, University of St Andrews, St Andrews, Fife KY16 9TS, UK.
pubmed:publicationType
Journal Article