| pubmed-article:9489710 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9489710 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:9489710 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:9489710 | lifeskim:mentions | umls-concept:C0138515 | lld:lifeskim |
| pubmed-article:9489710 | lifeskim:mentions | umls-concept:C0086860 | lld:lifeskim |
| pubmed-article:9489710 | lifeskim:mentions | umls-concept:C0014290 | lld:lifeskim |
| pubmed-article:9489710 | lifeskim:mentions | umls-concept:C0699032 | lld:lifeskim |
| pubmed-article:9489710 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:9489710 | pubmed:dateCreated | 1998-3-12 | lld:pubmed |
| pubmed-article:9489710 | pubmed:abstractText | Induction of the prodynorphin gene occurs in a tissue-specific manner following different physiological stimuli. Using electrophoretic mobility shift assays, we studied the relative activity of the five major regulatory sites in the rat prodynorphin promoter. Prodynorphin cyclic AMP-responsive element 2 (DynCRE2), DynCRE3, and the noncanonical prodynorphin AP-1 (ncDynAP-1) regulatory sites control, in a coordinated manner, prodynorphin induction in the spinal cord after noxious stimulation, whereas prodynorphin up-regulation in supraoptic neurons is regulated predominantly by the ncDynAP-1. Conversely, prodynorphin transactivation in the ovaries upon gonadotropin stimulation is controlled by DynCRE1 and DynCRE3. Our results support the idea that stimulus-specific changes in nuclear proteins establish a functional hierarchy among regulatory sites in the prodynorphin promoter and provide further insight in the molecular mechanisms that govern prodynorphin gene regulation. | lld:pubmed |
| pubmed-article:9489710 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9489710 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9489710 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9489710 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9489710 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9489710 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9489710 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9489710 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9489710 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9489710 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9489710 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9489710 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:9489710 | pubmed:issn | 0022-3042 | lld:pubmed |
| pubmed-article:9489710 | pubmed:author | pubmed-author:MellströmBB | lld:pubmed |
| pubmed-article:9489710 | pubmed:author | pubmed-author:LuckmanS MSM | lld:pubmed |
| pubmed-article:9489710 | pubmed:author | pubmed-author:NaranjoJ RJR | lld:pubmed |
| pubmed-article:9489710 | pubmed:author | pubmed-author:CarriónA MAM | lld:pubmed |
| pubmed-article:9489710 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9489710 | pubmed:volume | 70 | lld:pubmed |
| pubmed-article:9489710 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9489710 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9489710 | pubmed:pagination | 914-21 | lld:pubmed |
| pubmed-article:9489710 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:9489710 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9489710 | pubmed:articleTitle | Stimulus-specific hierarchy of enhancer elements within the rat prodynorphin promoter. | lld:pubmed |
| pubmed-article:9489710 | pubmed:affiliation | Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid, Spain. | lld:pubmed |
| pubmed-article:9489710 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9489710 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9489710 | lld:pubmed |
