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pubmed-article:9488311pubmed:abstractTextMinimizing secondary injury after severe traumatic brain injury (TBI) is the primary goal of cerebral resuscitation. For more than two decades, hyperventilation has been one of the most often used strategies in the management of TBI. Laboratory and clinical studies, however, have verified a post-TBI state of reduced cerebral perfusion that may increase the brain's vulnerability to secondary injury. In addition, it has been suggested in a clinical study that hyperventilation may worsen outcome after TBI.lld:pubmed
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pubmed-article:9488311pubmed:articleTitleAugmented neuronal death in CA3 hippocampus following hyperventilation early after controlled cortical impact.lld:pubmed
pubmed-article:9488311pubmed:affiliationSafar Center for Resuscitation Research, The University of Pittsburgh Brain Trauma Research Center, and Department of Anesthesiology/Critical Care Medicine, Pennsylvania 15260, USA.lld:pubmed
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