rdf:type |
|
lifeskim:mentions |
umls-concept:C0007578,
umls-concept:C0017262,
umls-concept:C0040648,
umls-concept:C0064568,
umls-concept:C0079904,
umls-concept:C0185117,
umls-concept:C0205263,
umls-concept:C0225336,
umls-concept:C1710082,
umls-concept:C1879547,
umls-concept:C2911684
|
pubmed:issue |
12 Pt 2
|
pubmed:dateCreated |
1998-4-2
|
pubmed:abstractText |
The adhesion of monocytes to endothelium, an early event in atherosclerosis is mediated by cell adhesion molecules. Signal-transduction pathways for these binding molecules include the translocation of the transcription factor NF-kappaB; moreover, intracellularly generated oxygen-derived free radicals play a major role in this process. In this study we evaluated the extent to which lacidipine, a calcium antagonist with antioxidant properties, affects the expression of intercellular cell adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin on human umbilical vein endothelial cells, induced by different pro-oxidant signals such as oxidized low density lipoprotein (LDL) and tumor necrosis factor-alpha (TNF-alpha).
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Dec
|
pubmed:issn |
0263-6352
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
15
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1633-40
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:9488215-Calcium Channel Blockers,
pubmed-meshheading:9488215-Cell Adhesion Molecules,
pubmed-meshheading:9488215-Cells, Cultured,
pubmed-meshheading:9488215-Dihydropyridines,
pubmed-meshheading:9488215-Dose-Response Relationship, Drug,
pubmed-meshheading:9488215-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:9488215-Endothelium, Vascular,
pubmed-meshheading:9488215-Humans,
pubmed-meshheading:9488215-Lipoproteins, LDL,
pubmed-meshheading:9488215-NF-kappa B,
pubmed-meshheading:9488215-Oxidation-Reduction,
pubmed-meshheading:9488215-Tumor Necrosis Factor-alpha,
pubmed-meshheading:9488215-Umbilical Veins
|
pubmed:year |
1997
|
pubmed:articleTitle |
Lacidipine inhibits the activation of the transcription factor NF-kappaB and the expression of adhesion molecules induced by pro-oxidant signals on endothelial cells.
|
pubmed:affiliation |
Istituto di Semeiotica e Nefrologia Medica, Università di Verona, Italy.
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|