Linked Life Data

9486649

Source:http://linkedlifedata.com/resource/pubmed/id/9486649

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6669
pubmed:dateCreated
1998-3-9
pubmed:abstractText
The generation of cellular diversity is essential in embryogenesis, especially in the central nervous system. During neurogenesis, cell interactions or asymmetric protein localization during mitosis can generate daughter cells with different fates. Here we describe the asymmetric localization of a messenger RNA and an RNA-binding protein that creates molecular and developmental differences between Drosophila neural precursors (neuroblasts) and their daughter cells, ganglion mother cells (GMCs). The prospero (pros) mRNA and the RNA-binding protein Staufen (Stau) are asymmetrically localized in mitotic neuroblasts and are specifically partitioned into the GMC, as is Pros protein. Stau is required for localization of pros RNA but not of Pros protein. Loss of localization of Stau or of pros RNA alters GMC development, but only in embryos with reduced levels of Pros protein, suggesting that pros RNA and Pros protein act redundantly to specify GMC fate. We also find that GMCs do not transcribe the pros gene, showing that inheritance of pros RNA and/or Pros protein from the neuroblast is essential for GMC specification.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0028-0836
pubmed:author
pubmed:issnType
Print
pubmed:day
19
pubmed:volume
391
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
792-5
pubmed:dateRevised
2008-10-16
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Staufen-dependent localization of prospero mRNA contributes to neuroblast daughter-cell fate.
pubmed:affiliation
Department of Cell & Structural Biology, Howard Hughes Medical Institute, University of Illinois, Urbana 61801, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't