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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
|
| pubmed:dateCreated |
1998-4-14
|
| pubmed:databankReference | |
| pubmed:abstractText |
In Drosophila the decision processes between the neural and epidermal fate for equipotent ectodermal cells depend on the activity of proneural genes. Members of the Drosophila Iroquois-Complex (Iro-C) positively regulate the activity of certain proneural AS-C genes during the formation of external sensory organs. We have identified and characterized three mouse Iroquois-related genes: Irx1, -2 and -3, which have a homeodomain very similar to that of the Drosophila Iro-C genes. The sequence similarity implies that these three genes represent a separate homeobox family. All three genes are expressed with distinct spatio/temporal patterns during early mouse embryogenesis. These patterns implicate them in a number of embryonic developmental processes: the A/P and D/V patterning of specific regions of the central nervous system (CNS), and regionalization of the otic vesicle, branchial epithelium and limbs.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0925-4773
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
69
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
169-81
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9486539-Amino Acid Sequence,
pubmed-meshheading:9486539-Animals,
pubmed-meshheading:9486539-Blotting, Northern,
pubmed-meshheading:9486539-Conserved Sequence,
pubmed-meshheading:9486539-Drosophila,
pubmed-meshheading:9486539-Ear,
pubmed-meshheading:9486539-Extremities,
pubmed-meshheading:9486539-Gene Expression Regulation, Developmental,
pubmed-meshheading:9486539-Homeodomain Proteins,
pubmed-meshheading:9486539-In Situ Hybridization,
pubmed-meshheading:9486539-Mice,
pubmed-meshheading:9486539-Mice, Inbred C57BL,
pubmed-meshheading:9486539-Molecular Sequence Data,
pubmed-meshheading:9486539-Nervous System,
pubmed-meshheading:9486539-Sequence Homology, Amino Acid,
pubmed-meshheading:9486539-Tissue Distribution,
pubmed-meshheading:9486539-Transcription, Genetic,
pubmed-meshheading:9486539-Transcription Factors,
pubmed-meshheading:9486539-Vertebrates
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Identification of the vertebrate Iroquois homeobox gene family with overlapping expression during early development of the nervous system.
|
| pubmed:affiliation |
Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Göttingen, Germany.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|