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| pubmed-article:9486406 | lifeskim:mentions | umls-concept:C0004359 | lld:lifeskim |
| pubmed-article:9486406 | lifeskim:mentions | umls-concept:C0006556 | lld:lifeskim |
| pubmed-article:9486406 | lifeskim:mentions | umls-concept:C0599894 | lld:lifeskim |
| pubmed-article:9486406 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:9486406 | lifeskim:mentions | umls-concept:C1515021 | lld:lifeskim |
| pubmed-article:9486406 | lifeskim:mentions | umls-concept:C0205165 | lld:lifeskim |
| pubmed-article:9486406 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:9486406 | lifeskim:mentions | umls-concept:C1521840 | lld:lifeskim |
| pubmed-article:9486406 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:9486406 | pubmed:dateCreated | 1998-3-13 | lld:pubmed |
| pubmed-article:9486406 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9486406 | pubmed:abstractText | Using autoimmune serum from a patient with anti-centromere antibodies, we have identified and partially characterized a novel protein with a mol. wt of approximately 27 kD (hereafter referred to as p27). A cDNA expression library was screened with this serum, and two overlapping inserts were isolated among three positive clones other than clones corresponding to centromere protein (CENP)-B and CENP-C. Analysis of the sequence showed an open reading frame of approximately 0.6 kb encoding 199 amino acids with a predicted mol. wt of 21.5 kD. Immunoblotting analysis with bacterial recombinant p27 showed that approximately 2% of anti-centromere antibody-positive patients had autoantibodies to p27, whereas only one of 215 autoimmune patients without anti-centromere antibodies reacted with the recombinant. All five cases with anti-p27 antibodies, who were diagnosed as having scleroderma and/or Sjögren's syndrome, showed internal organ involvement. Although affinity-purified anti-p27 human or mouse polyclonal antibodies failed to stain any cellular structures in an immunofluorescence study, the potential association of anti-p27 with anti-centromere antibodies suggests that this novel autoantigen might play a role in mitosis. | lld:pubmed |
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| pubmed-article:9486406 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9486406 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9486406 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9486406 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9486406 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:9486406 | pubmed:issn | 0009-9104 | lld:pubmed |
| pubmed-article:9486406 | pubmed:author | pubmed-author:YamadaTT | lld:pubmed |
| pubmed-article:9486406 | pubmed:author | pubmed-author:SugimotoKK | lld:pubmed |
| pubmed-article:9486406 | pubmed:author | pubmed-author:HimenoMM | lld:pubmed |
| pubmed-article:9486406 | pubmed:author | pubmed-author:MusaJJ | lld:pubmed |
| pubmed-article:9486406 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9486406 | pubmed:volume | 111 | lld:pubmed |
| pubmed-article:9486406 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9486406 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9486406 | pubmed:pagination | 372-6 | lld:pubmed |
| pubmed-article:9486406 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:9486406 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9486406 | pubmed:articleTitle | cDNA cloning of a novel autoantigen targeted by a minor subset of anti-centromere antibodies. | lld:pubmed |
| pubmed-article:9486406 | pubmed:affiliation | Department of Dermatology, Nagoya University School of Medicine, Japan. | lld:pubmed |
| pubmed-article:9486406 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9486406 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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