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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2 Pt 1
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pubmed:dateCreated |
1998-3-23
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pubmed:abstractText |
We hypothesized that capillary recruitment may not be solely dependent on extracapillary factors. To test this hypothesis, rabbits were anesthetized and placed on total cardiac bypass at a constant, physiological pulmonary blood flow. Vascular occlusion techniques were combined with measurement of the transpulmonary metabolism of an angiotensin-converting enzyme substrate, allowing the concomitant assessment of changes in segmental resistances and dynamically perfused capillary surface area. Intra-arterial serotonin infusion increased upstream pulmonary vascular resistances without affecting dynamically perfused capillary surface area. Intra-arterial isoproterenol infusion diminished serotonin-induced increased upstream resistances, also without affecting capillary surface area. These findings support the hypothesis that pulmonary capillary recruitment may not be solely dependent on extracapillary factors.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0002-9513
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
274
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
L264-9
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:9486212-Animals,
pubmed-meshheading:9486212-Capillaries,
pubmed-meshheading:9486212-Capillary Resistance,
pubmed-meshheading:9486212-Hypertension, Pulmonary,
pubmed-meshheading:9486212-Isoproterenol,
pubmed-meshheading:9486212-Microcirculation,
pubmed-meshheading:9486212-Pulmonary Circulation,
pubmed-meshheading:9486212-Rabbits,
pubmed-meshheading:9486212-Serotonin,
pubmed-meshheading:9486212-Surface Properties
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pubmed:year |
1998
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pubmed:articleTitle |
Unaltered pulmonary capillary surface area in the presence of changing arterial resistance.
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pubmed:affiliation |
Department of Pediatrics, Medical College of Georgia, Augusta 30912, USA.
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pubmed:publicationType |
Journal Article
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