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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1998-3-2
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pubmed:abstractText |
To determine if prolonged immune activation may be associated with the persistence of anaemia after treatment for severe malaria, we measured serum concentrations of neopterin and interleukin-4 during one week of antimalarial therapy and determined haemoglobin levels one month later. Neopterin is a clinically valuable marker for monitoring activation of macrophages by gamma-interferon and thus reflects the TH-1 immune response. Interleukin-4 is a major cytokine that tends to be inhibited by TH-1 activity.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1360-2276
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
60-5
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9484971-Analysis of Variance,
pubmed-meshheading:9484971-Anemia,
pubmed-meshheading:9484971-Antimalarials,
pubmed-meshheading:9484971-Child, Preschool,
pubmed-meshheading:9484971-Deferoxamine,
pubmed-meshheading:9484971-Drug Therapy, Combination,
pubmed-meshheading:9484971-Female,
pubmed-meshheading:9484971-Follow-Up Studies,
pubmed-meshheading:9484971-Hemoglobins,
pubmed-meshheading:9484971-Humans,
pubmed-meshheading:9484971-Infant,
pubmed-meshheading:9484971-Interleukin-10,
pubmed-meshheading:9484971-Interleukin-4,
pubmed-meshheading:9484971-Interleukin-6,
pubmed-meshheading:9484971-Macrophage Activation,
pubmed-meshheading:9484971-Malaria, Cerebral,
pubmed-meshheading:9484971-Male,
pubmed-meshheading:9484971-Neopterin,
pubmed-meshheading:9484971-Pyrimethamine,
pubmed-meshheading:9484971-Quinine,
pubmed-meshheading:9484971-Retrospective Studies,
pubmed-meshheading:9484971-Sulfadoxine
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pubmed:year |
1998
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pubmed:articleTitle |
Prolonged macrophage activation and persistent anaemia in children with complicated malaria.
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pubmed:affiliation |
Macha Mission Hospital, Choma, Zambia.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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