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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1998-3-17
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pubmed:abstractText |
A novel non-pyrogenic carbocyclic muramyl dipeptide (MDP) analogue, N-¿trans-2-[[2'-(acetylamino)cyclohexyl]oxy]acetyl¿-L-alanyl-D-glutamic acid, was obtained by replacement of the N-acetylmuramic acid part and the D-isoglutamine residue of the MDP molecule by a trans-2-[[2'-(acetylamino)cyclohexyl]oxy]acetyl moiety and D-glutamic acid, respectively. The title compound was selected as a promising candidate for further evaluation among several related analogues on the basis of an immunorestoration test in mice. This novel nor-MDP analogue protects mice against the immunosuppressive effect of cyclophosphamide and increases the nonspecific resistance of mice against fungal infection. It is an immunomodulator which enhances the maturation of lymphocytes B to plasma cells and increases the activity of lymphocytes B and lymphocytes T as well as that of macrophages but does not alter the number of these cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0022-2623
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pubmed:author |
pubmed-author:GrahekRR,
pubmed-author:HönigHH,
pubmed-author:HocevarMM,
pubmed-author:IhanAA,
pubmed-author:KikeljDD,
pubmed-author:KlamferLL,
pubmed-author:KotnikVV,
pubmed-author:PecarSS,
pubmed-author:PovsicLL,
pubmed-author:Rogi-KohlenprathRR,
pubmed-author:SimcicSS,
pubmed-author:StalcAA,
pubmed-author:SuhadolcEE,
pubmed-author:Wraber-HerzogBB
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pubmed:issnType |
Print
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pubmed:day |
12
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
530-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9484503-Acetylmuramyl-Alanyl-Isoglutamine,
pubmed-meshheading:9484503-Adjuvants, Immunologic,
pubmed-meshheading:9484503-Animals,
pubmed-meshheading:9484503-B-Lymphocytes,
pubmed-meshheading:9484503-Cyclophosphamide,
pubmed-meshheading:9484503-Female,
pubmed-meshheading:9484503-Immune Tolerance,
pubmed-meshheading:9484503-Immunosuppressive Agents,
pubmed-meshheading:9484503-Indicators and Reagents,
pubmed-meshheading:9484503-Lymphocyte Activation,
pubmed-meshheading:9484503-Macrophages,
pubmed-meshheading:9484503-Mice,
pubmed-meshheading:9484503-Mice, Inbred Strains,
pubmed-meshheading:9484503-Models, Molecular,
pubmed-meshheading:9484503-Molecular Structure,
pubmed-meshheading:9484503-Plasma Cells,
pubmed-meshheading:9484503-Spleen,
pubmed-meshheading:9484503-Stereoisomerism,
pubmed-meshheading:9484503-T-Lymphocytes
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pubmed:year |
1998
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pubmed:articleTitle |
N-[trans-2-[[2'-(acetylamino)cyclohexyl]oxy]acetyl]-L-alanyl-D-glutamic acid: a novel immunologically active carbocyclic muramyl dipeptide analogue.
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pubmed:affiliation |
Faculty of Pharmacy, University of Ljubljana, Slovenia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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