| pubmed-article:9483375 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9483375 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:9483375 | lifeskim:mentions | umls-concept:C0011854 | lld:lifeskim |
| pubmed-article:9483375 | lifeskim:mentions | umls-concept:C0521451 | lld:lifeskim |
| pubmed-article:9483375 | lifeskim:mentions | umls-concept:C0004358 | lld:lifeskim |
| pubmed-article:9483375 | lifeskim:mentions | umls-concept:C0017875 | lld:lifeskim |
| pubmed-article:9483375 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:9483375 | pubmed:dateCreated | 1998-4-17 | lld:pubmed |
| pubmed-article:9483375 | pubmed:abstractText | The mitochondrial enzyme FAD-linked glycerophosphate dehydrogenase (mGDH) plays a key role in the recognition of D-glucose as a stimulus for insulin release from the pancreatic islet B-cell. This study reveals that autoantibodies against this enzyme are not uncommonly found in patients with insulin-dependent diabetes mellitus (IDDM) examined at the onset of the disease. Antibodies reacting with a recombinant mGDH fragment product were observed in the serum of four out of 15 type-1 diabetics, but in none of 15 control subjects. The serum of patients positive for the recombinant mGDH fragment also recognized native mGDH in a rat testis extract, provided that the enzymatic protein was first exposed to an anti-mGDH rabbit serum. Antibodies against mGDH were also found in four out 12 patients with autoimmune thyroiditis. These findings reveal that a mitochondrial enzyme, that represents an essential component of the islet B-cell glucose-sensing device, may act as an antigenic determinant in patients with IDDM or other autoimmune diseases. | lld:pubmed |
| pubmed-article:9483375 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9483375 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9483375 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9483375 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9483375 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9483375 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9483375 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9483375 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9483375 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9483375 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:9483375 | pubmed:issn | 0168-8227 | lld:pubmed |
| pubmed-article:9483375 | pubmed:author | pubmed-author:RodriguezCC | lld:pubmed |
| pubmed-article:9483375 | pubmed:author | pubmed-author:MalaisseW JWJ | lld:pubmed |
| pubmed-article:9483375 | pubmed:author | pubmed-author:GallartTT | lld:pubmed |
| pubmed-article:9483375 | pubmed:author | pubmed-author:GomisRR | lld:pubmed |
| pubmed-article:9483375 | pubmed:author | pubmed-author:NovialsAA | lld:pubmed |
| pubmed-article:9483375 | pubmed:author | pubmed-author:GastAA | lld:pubmed |
| pubmed-article:9483375 | pubmed:author | pubmed-author:FabregatM EME | lld:pubmed |
| pubmed-article:9483375 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9483375 | pubmed:volume | 38 | lld:pubmed |
| pubmed-article:9483375 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9483375 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9483375 | pubmed:pagination | 115-21 | lld:pubmed |
| pubmed-article:9483375 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:9483375 | pubmed:meshHeading | pubmed-meshheading:9483375-... | lld:pubmed |
| pubmed-article:9483375 | pubmed:meshHeading | pubmed-meshheading:9483375-... | lld:pubmed |
| pubmed-article:9483375 | pubmed:meshHeading | pubmed-meshheading:9483375-... | lld:pubmed |
| pubmed-article:9483375 | pubmed:meshHeading | pubmed-meshheading:9483375-... | lld:pubmed |
| pubmed-article:9483375 | pubmed:meshHeading | pubmed-meshheading:9483375-... | lld:pubmed |
| pubmed-article:9483375 | pubmed:meshHeading | pubmed-meshheading:9483375-... | lld:pubmed |
| pubmed-article:9483375 | pubmed:meshHeading | pubmed-meshheading:9483375-... | lld:pubmed |
| pubmed-article:9483375 | pubmed:meshHeading | pubmed-meshheading:9483375-... | lld:pubmed |
| pubmed-article:9483375 | pubmed:meshHeading | pubmed-meshheading:9483375-... | lld:pubmed |
| pubmed-article:9483375 | pubmed:meshHeading | pubmed-meshheading:9483375-... | lld:pubmed |
| pubmed-article:9483375 | pubmed:meshHeading | pubmed-meshheading:9483375-... | lld:pubmed |
| pubmed-article:9483375 | pubmed:meshHeading | pubmed-meshheading:9483375-... | lld:pubmed |
| pubmed-article:9483375 | pubmed:meshHeading | pubmed-meshheading:9483375-... | lld:pubmed |
| pubmed-article:9483375 | pubmed:meshHeading | pubmed-meshheading:9483375-... | lld:pubmed |
| pubmed-article:9483375 | pubmed:meshHeading | pubmed-meshheading:9483375-... | lld:pubmed |
| pubmed-article:9483375 | pubmed:meshHeading | pubmed-meshheading:9483375-... | lld:pubmed |
| pubmed-article:9483375 | pubmed:meshHeading | pubmed-meshheading:9483375-... | lld:pubmed |
| pubmed-article:9483375 | pubmed:meshHeading | pubmed-meshheading:9483375-... | lld:pubmed |
| pubmed-article:9483375 | pubmed:meshHeading | pubmed-meshheading:9483375-... | lld:pubmed |
| pubmed-article:9483375 | pubmed:meshHeading | pubmed-meshheading:9483375-... | lld:pubmed |
| pubmed-article:9483375 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9483375 | pubmed:articleTitle | Autoantibodies against mitochondrial glycerophosphate dehydrogenase in patients with IDDM. | lld:pubmed |
| pubmed-article:9483375 | pubmed:affiliation | Endocrinology Unit, Hospital Clinic, Barcelona, Spain. | lld:pubmed |
| pubmed-article:9483375 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9483375 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
