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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1998-4-17
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pubmed:abstractText |
The mitochondrial enzyme FAD-linked glycerophosphate dehydrogenase (mGDH) plays a key role in the recognition of D-glucose as a stimulus for insulin release from the pancreatic islet B-cell. This study reveals that autoantibodies against this enzyme are not uncommonly found in patients with insulin-dependent diabetes mellitus (IDDM) examined at the onset of the disease. Antibodies reacting with a recombinant mGDH fragment product were observed in the serum of four out of 15 type-1 diabetics, but in none of 15 control subjects. The serum of patients positive for the recombinant mGDH fragment also recognized native mGDH in a rat testis extract, provided that the enzymatic protein was first exposed to an anti-mGDH rabbit serum. Antibodies against mGDH were also found in four out 12 patients with autoimmune thyroiditis. These findings reveal that a mitochondrial enzyme, that represents an essential component of the islet B-cell glucose-sensing device, may act as an antigenic determinant in patients with IDDM or other autoimmune diseases.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0168-8227
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
38
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
115-21
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9483375-Adolescent,
pubmed-meshheading:9483375-Adult,
pubmed-meshheading:9483375-Aged,
pubmed-meshheading:9483375-Animals,
pubmed-meshheading:9483375-Autoantibodies,
pubmed-meshheading:9483375-Diabetes Mellitus, Type 1,
pubmed-meshheading:9483375-Female,
pubmed-meshheading:9483375-Glutathione Transferase,
pubmed-meshheading:9483375-Glycerolphosphate Dehydrogenase,
pubmed-meshheading:9483375-Humans,
pubmed-meshheading:9483375-Immune Sera,
pubmed-meshheading:9483375-Immunoblotting,
pubmed-meshheading:9483375-Male,
pubmed-meshheading:9483375-Middle Aged,
pubmed-meshheading:9483375-Mitochondria,
pubmed-meshheading:9483375-Rabbits,
pubmed-meshheading:9483375-Rats,
pubmed-meshheading:9483375-Recombinant Proteins,
pubmed-meshheading:9483375-Testis,
pubmed-meshheading:9483375-Thyroiditis, Autoimmune
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pubmed:year |
1997
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pubmed:articleTitle |
Autoantibodies against mitochondrial glycerophosphate dehydrogenase in patients with IDDM.
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pubmed:affiliation |
Endocrinology Unit, Hospital Clinic, Barcelona, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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