| pubmed-article:9480829 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9480829 | lifeskim:mentions | umls-concept:C1533698 | lld:lifeskim |
| pubmed-article:9480829 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:9480829 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:9480829 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:9480829 | lifeskim:mentions | umls-concept:C0243077 | lld:lifeskim |
| pubmed-article:9480829 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:9480829 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:9480829 | pubmed:dateCreated | 1998-3-27 | lld:pubmed |
| pubmed-article:9480829 | pubmed:abstractText | In murine macrophages, inducible NO synthase II (iNOS or NOS-II) is induced at the transcriptional level by IFN-gamma, alone or synergistically with LPS. We investigated the possible role of reactions of ADP-ribosylation in triggering the signaling pathways involved in NOS-II gene expression. Stimulation with IFN-gamma and/or LPS of RAW 264.7 macrophages, transiently transfected with the NOS-II promoter, was inhibited by ADP-ribosylation inhibitors, indicating that they interfered with the signal(s) responsible for NOS-II gene transcription. We therefore explored the effect of these inhibitors on the activity of IRF-1 and NF kappa B transcription factors known to be involved in NOS-II induction by IFN-gamma and LPS. No effect was observed on IRF-1 activation. However, NF kappa B binding to its target sequence diminished and transfection experiments with an NF kappa B-driven reporter plasmid demonstrating that ADP-ribosylation inhibitors suppressed NF kappa B-dependent promoter activity. These results provide evidence that a step involving ADP-ribosylation is required to activate NF kappa B-mediated gene transcription. | lld:pubmed |
| pubmed-article:9480829 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9480829 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9480829 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9480829 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9480829 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9480829 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:9480829 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:9480829 | pubmed:author | pubmed-author:WietzerbinJJ | lld:pubmed |
| pubmed-article:9480829 | pubmed:author | pubmed-author:SanceauJJ | lld:pubmed |
| pubmed-article:9480829 | pubmed:author | pubmed-author:DrapierJ CJC | lld:pubmed |
| pubmed-article:9480829 | pubmed:author | pubmed-author:Le PageCC | lld:pubmed |
| pubmed-article:9480829 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9480829 | pubmed:day | 13 | lld:pubmed |
| pubmed-article:9480829 | pubmed:volume | 243 | lld:pubmed |
| pubmed-article:9480829 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9480829 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9480829 | pubmed:pagination | 451-7 | lld:pubmed |
| pubmed-article:9480829 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:9480829 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9480829 | pubmed:articleTitle | Inhibitors of ADP-ribosylation impair inducible nitric oxide synthase gene transcription through inhibition of NF kappa B activation. | lld:pubmed |
| pubmed-article:9480829 | pubmed:affiliation | Unité 365 INSERM Interférons et Cytokines Institut Curie, Paris, France. | lld:pubmed |
| pubmed-article:9480829 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9480829 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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