| pubmed-article:9480727 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9480727 | lifeskim:mentions | umls-concept:C0012171 | lld:lifeskim |
| pubmed-article:9480727 | lifeskim:mentions | umls-concept:C0034699 | lld:lifeskim |
| pubmed-article:9480727 | lifeskim:mentions | umls-concept:C0030274 | lld:lifeskim |
| pubmed-article:9480727 | lifeskim:mentions | umls-concept:C0699819 | lld:lifeskim |
| pubmed-article:9480727 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:9480727 | lifeskim:mentions | umls-concept:C1333196 | lld:lifeskim |
| pubmed-article:9480727 | lifeskim:mentions | umls-concept:C1423842 | lld:lifeskim |
| pubmed-article:9480727 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:9480727 | pubmed:dateCreated | 1998-3-10 | lld:pubmed |
| pubmed-article:9480727 | pubmed:abstractText | The effect of dietary n-3 or n-6 polyunsaturated fatty acids on the development of autoimmune insulitis was analysed in diabetes-prone BB rats. Litter-matched groups of rats received a standard open formula NIH-07 (National Institutes of Health, NIH) diet enriched with 10% fish oil, 10% flaxseed oil or with 10% palm oil plus 2% cholesterol during the period of insulitis onset (50-70 days of age). Analysis of cytokine gene expression in pancreatic RNA revealed an increase of IFN-gamma and a decrease of IL-10 mRNA with onset of insulitis. When compared to unsupplemented NIH, none of the three fat-enriched diets depressed the rise of IFN-gamma gene expression or the influx of leukocytes into islets. However, all of the fat-enriched diets led to significantly higher IL-10 mRNA levels. Although a specific anti-inflammatory effect of fish oil was not seen in the pancreas, a clear shift of the Th1/Th2 cytokine mRNA ratio towards Th2 was seen in the gut-associated immune system. We conclude that diets high in fat support IL-10 without suppressing IFN-gamma gene expression in islet inflammation. A special anti-inflammatory effect of fish oil was not seen in pancreatic lesions of BB rats, although there was strong modulation of the IFN-gamma/IL-10 mRNA ratio in the gut associated immune system. | lld:pubmed |
| pubmed-article:9480727 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9480727 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9480727 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9480727 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9480727 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9480727 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9480727 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9480727 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9480727 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:9480727 | pubmed:issn | 0896-8411 | lld:pubmed |
| pubmed-article:9480727 | pubmed:author | pubmed-author:KolbHH | lld:pubmed |
| pubmed-article:9480727 | pubmed:author | pubmed-author:ScottF WFW | lld:pubmed |
| pubmed-article:9480727 | pubmed:author | pubmed-author:KleemannRR | lld:pubmed |
| pubmed-article:9480727 | pubmed:author | pubmed-author:Wörz-Pagenste... | lld:pubmed |
| pubmed-article:9480727 | pubmed:author | pubmed-author:Nimal... | lld:pubmed |
| pubmed-article:9480727 | pubmed:copyrightInfo | Copyright 1998 Academic Press Limited. | lld:pubmed |
| pubmed-article:9480727 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9480727 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:9480727 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9480727 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9480727 | pubmed:pagination | 97-103 | lld:pubmed |
| pubmed-article:9480727 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:9480727 | pubmed:meshHeading | pubmed-meshheading:9480727-... | lld:pubmed |
| pubmed-article:9480727 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9480727 | pubmed:articleTitle | Impact of dietary fat on Th1/Th2 cytokine gene expression in the pancreas and gut of diabetes-prone BB rats. | lld:pubmed |
| pubmed-article:9480727 | pubmed:affiliation | Diabetes Research Institute, University of Düsseldorf, Germany. | lld:pubmed |
| pubmed-article:9480727 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9480727 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9480727 | lld:pubmed |
