Linked Life Data

9480140

Source:http://linkedlifedata.com/resource/pubmed/id/9480140

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1998-2-25
pubmed:abstractText
The pathomechanism of desmopressin (DDAVP)-dependent shortening of the bleeding time prolonged by acetylsalicylic acid (ASA) was investigated by the Ivy bleeding time (BT) and the in vitro bleeding test (IVBT). Additionally, platelet aggregation and von Willebrand factor (vWF) were determined. The possible effect on plasma or platelets was examined by blood compositions containing citrated whole blood after ingestion of ASA plus either plasma or platelets after application of DDAVP (control: plasma or platelets after ASA). Excellent correlations were found between BT and IVBT as well as vWF (r2 = 0.97-0.99). In contrast, platelet aggregation decreased after administration of DDAVP. Experiments with blood compositions showed an effect of plasma and platelets as well in the IVBT after DDAVP administration. The results demonstrate the superiority of the IVBT to describe the in vivo function of platelets in comparison with the platelet aggregation test.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1023-2028
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
437-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
[Shortening of acetylsalicylic acid-prolonged bleeding time by means of desmopressin].
pubmed:affiliation
Abteilung Transfusionsmedizin and Hämostaseologie, Universitäts-Klinik Marburg, Deutschland.
pubmed:publicationType
Journal Article, Comparative Study, English Abstract