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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1998-2-25
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pubmed:abstractText |
Neonatal alloimmune thrombocytopenia (NAIT) is caused by maternal immunization against a paternal antigen on fetal platelets. The antigens mostly involved are Zwa (PlA1) and Br(a). The Ko alloantigen system which is localized on the N-terminal region of glycoprotein Ib usually causes antibody formation in polytransfused patients but is only rarely implicated in NAIT. Ko(a) antibodies raised in the mother of a thrombocytopenic newborn were shown to be detectable by platelet agglutination and MAIPA assay if the antigen-bearing N-terminal glycocalicin is protected from proteolytic degradation.
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pubmed:language |
ger
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1023-2028
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
32
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
244-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9480100-Antigens, Human Platelet,
pubmed-meshheading:9480100-Blood Platelets,
pubmed-meshheading:9480100-Female,
pubmed-meshheading:9480100-Humans,
pubmed-meshheading:9480100-Infant, Newborn,
pubmed-meshheading:9480100-Isoantibodies,
pubmed-meshheading:9480100-Male,
pubmed-meshheading:9480100-Platelet Glycoprotein GPIb-IX Complex,
pubmed-meshheading:9480100-Pregnancy,
pubmed-meshheading:9480100-Purpura, Thrombocytopenic, Idiopathic
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pubmed:year |
1994
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pubmed:articleTitle |
[Anti Ko(a) as a cause of neonatal alloimmune thrombocytopenia].
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pubmed:affiliation |
Institut für Klinische Immunologie und Transfusionsmedizin, Justus-Liebig-Universität Giessen, Deutschland.
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pubmed:publicationType |
Journal Article,
English Abstract
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