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PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1998-4-2
pubmed:abstractText
We examined secretion, mRNA expression, and histologic localization of interleukin-8 (IL-*) and growth-related gene product-alpha (GRO alpha) in the Helicobacter pylori-infected gastric antral mucosa. Antral biopsies were obtained from an area of endoscopically intact mucosa. Significantly higher levels of IL-8 and GRO alpha were secreted in organ cultures from patients with H. pylori infection, and their elevation was prominent in patients with duodenal ulcer. There was a significant association between these alpha-chemokine levels and histologic grades of activity, inflammation, and H. pylori density. In fresh antral biopsies, IL-8 and GRO alpha mRNA expression was detected more frequently in H. pylori-infected patients compared with those without infection. Immunofluorescence microscopy showed localization of IL-8 and GRO alpha proteins in gastric epithelial cells and infiltrating CD68+ macrophages. In the chemotaxis assay, a significant positive correlation was found between neutrophil migration induced by the organ culture supernatants and their contents of IL-8 and GRO alpha. After H. pylori eradication, a significant decrease was observed in IL-8 and GRO alpha levels detected in organ cultures. In conclusion, mucosal alpha-chemokine activity correlates well with histologic severity of H. pylori-associated antral gastritis and can be used to predict the effects of H. pylori eradication therapy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0192-0790
pubmed:author
pubmed:issnType
Print
pubmed:volume
25 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S203-10
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:9479649-Adult, pubmed-meshheading:9479649-Biopsy, pubmed-meshheading:9479649-Chemokine CXCL1, pubmed-meshheading:9479649-Chemokines, pubmed-meshheading:9479649-Chemokines, CXC, pubmed-meshheading:9479649-Chemotactic Factors, pubmed-meshheading:9479649-Chemotaxis, Leukocyte, pubmed-meshheading:9479649-Female, pubmed-meshheading:9479649-Fluorescent Antibody Technique, Indirect, pubmed-meshheading:9479649-Gastric Mucosa, pubmed-meshheading:9479649-Gastritis, pubmed-meshheading:9479649-Gene Expression, pubmed-meshheading:9479649-Growth Substances, pubmed-meshheading:9479649-Helicobacter Infections, pubmed-meshheading:9479649-Helicobacter pylori, pubmed-meshheading:9479649-Humans, pubmed-meshheading:9479649-Intercellular Signaling Peptides and Proteins, pubmed-meshheading:9479649-Interleukin-8, pubmed-meshheading:9479649-Male, pubmed-meshheading:9479649-Middle Aged, pubmed-meshheading:9479649-Neutrophils, pubmed-meshheading:9479649-Peptic Ulcer, pubmed-meshheading:9479649-Polymerase Chain Reaction, pubmed-meshheading:9479649-RNA, Messenger
pubmed:year
1997
pubmed:articleTitle
Mucosal chemokine activity in Helicobacter pylori infection.
pubmed:affiliation
First Department of Internal Medicine, Nagoya University School of Medicine, Japan.
pubmed:publicationType
Journal Article