Linked Life Data

9479582

Source:http://linkedlifedata.com/resource/pubmed/id/9479582

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1998-3-24
pubmed:abstractText
Mouse mammary tumor virus (MMTV) is a retrovirus that is transmitted through milk to offspring. Gut-associated B cells are the first cells to be infected during virus transmission, and these cells present a virus-encoded superantigen to cognate T cells. This allows MMTV to replicate and amplify in activated lymphocytes and ultimately results in virus transmission to the mammary epithelial cells. Because the superantigen has profound effects on the T cell repertoire and because MMTV replicates in lymphoid cells, loss of immune response to the virus may also play a role in its ability to persist within its host. Transcriptional control of MMTV expression also plays an important part in this pathway and DNA recognition sequences for transcription factors that allow its expression in lymphoid organs and mammary epithelia are encoded within the virus. Thus, this virus has evolved to take maximum advantage of its host's biology.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0257-277X
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
209-16
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Mouse mammary tumor virus and its interaction with the immune system.
pubmed:affiliation
Department of Microbiology, University of Pennsylvania, Philadelphia 19104-6142, USA. rosss@mail.med.upenn.edu
pubmed:publicationType
Journal Article, Review