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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1998-3-26
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pubmed:abstractText |
The retinoid X receptor (RXR) activates transcription of target genes in response to its natural ligand, 9-cis retinoic acid (9cRA), and a number of RXR-specific synthetic ligands. To discover the potential for engineering nuclear receptors for activation of transcription by novel ligands, we used structure-based mutagenesis to change the ligand specificity of RXR.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1074-5521
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
13-21
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:9479476-Amino Acid Sequence,
pubmed-meshheading:9479476-Ligands,
pubmed-meshheading:9479476-Models, Molecular,
pubmed-meshheading:9479476-Molecular Sequence Data,
pubmed-meshheading:9479476-Mutagenesis,
pubmed-meshheading:9479476-Protein Conformation,
pubmed-meshheading:9479476-Protein Engineering,
pubmed-meshheading:9479476-Receptors, Cell Surface,
pubmed-meshheading:9479476-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:9479476-Receptors, Retinoic Acid,
pubmed-meshheading:9479476-Retinoid X Receptors,
pubmed-meshheading:9479476-Sequence Alignment,
pubmed-meshheading:9479476-Sequence Homology, Amino Acid,
pubmed-meshheading:9479476-Transcription, Genetic,
pubmed-meshheading:9479476-Transcription Factors,
pubmed-meshheading:9479476-Transcriptional Activation
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pubmed:year |
1998
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pubmed:articleTitle |
Engineering novel specificities for ligand-activated transcription in the nuclear hormone receptor RXR.
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pubmed:affiliation |
Howard Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas 75235-9050, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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