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rdf:type |
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lifeskim:mentions |
umls-concept:C0015576,
umls-concept:C0026969,
umls-concept:C0040648,
umls-concept:C0080347,
umls-concept:C0204727,
umls-concept:C0205314,
umls-concept:C0205409,
umls-concept:C0441655,
umls-concept:C0599851,
umls-concept:C0679622,
umls-concept:C0680022,
umls-concept:C0920533,
umls-concept:C1521761,
umls-concept:C1880022
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pubmed:issue |
9
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pubmed:dateCreated |
1998-3-25
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pubmed:databankReference |
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pubmed:abstractText |
Myelin transcription factor 1 (MyT1) and neural zinc finger factor 1 (NZF-1) represent the first two members of an emerging family of neural specific, zinc finger-containing DNA-binding proteins. MyT1 has been shown recently to play a critical role in neuronal cell differentiation during development. We have cloned the third member of the NZF/MyT family, referred to as neural zinc finger factor 3 (NZF-3). The cDNA sequence predicts a protein of 1,032 amino acids which contains two clusters of zinc fingers similar to MyT1 and NZF-1. Unlike MyT1 and NZF-1, NZF-3 does not contain an acidic domain at the amino terminus or a serine/threonine-rich region between the two finger clusters. NZF-3 binds to a DNA element containing a single copy of the previously described AAAGTTT consensus motif for these factors but exhibits a marked enhancement in relative affinity to a bipartite element containing two copies of the consensus motif. In contrast to MyT1 and NZF-1, which are known to activate transcription, cotransfection experiments revealed that NZF-3 confers repression on the basal activity of promoters containing the consensus binding elements. The identification of an additional member of the NZF/MyT family provides an opportunity to investigate the relative contribution of members of this family of transcription factors to the complex regulatory processes in neural development and homeostasis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/MYT1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Myt1 kinase, rat,
http://linkedlifedata.com/resource/pubmed/chemical/NZF-1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/PKMYT1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0021-9258
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
27
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pubmed:volume |
273
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5366-74
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:9478997-Amino Acid Sequence,
pubmed-meshheading:9478997-Animals,
pubmed-meshheading:9478997-Base Sequence,
pubmed-meshheading:9478997-Cloning, Molecular,
pubmed-meshheading:9478997-DNA, Complementary,
pubmed-meshheading:9478997-DNA-Binding Proteins,
pubmed-meshheading:9478997-Gene Expression Regulation,
pubmed-meshheading:9478997-Humans,
pubmed-meshheading:9478997-Membrane Proteins,
pubmed-meshheading:9478997-Molecular Sequence Data,
pubmed-meshheading:9478997-Multigene Family,
pubmed-meshheading:9478997-Nerve Tissue Proteins,
pubmed-meshheading:9478997-Polymerase Chain Reaction,
pubmed-meshheading:9478997-Protein-Serine-Threonine Kinases,
pubmed-meshheading:9478997-Protein-Tyrosine Kinases,
pubmed-meshheading:9478997-Rats,
pubmed-meshheading:9478997-Repressor Proteins,
pubmed-meshheading:9478997-Sequence Analysis, DNA,
pubmed-meshheading:9478997-Sequence Homology, Amino Acid,
pubmed-meshheading:9478997-Sequence Homology, Nucleic Acid,
pubmed-meshheading:9478997-Trans-Activators,
pubmed-meshheading:9478997-Transcription, Genetic,
pubmed-meshheading:9478997-Transcription Factors,
pubmed-meshheading:9478997-Zinc Fingers
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pubmed:year |
1998
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pubmed:articleTitle |
Isolation and characterization of a novel member of the neural zinc finger factor/myelin transcription factor family with transcriptional repression activity.
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pubmed:affiliation |
Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609, Republic of Singapore.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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