Linked Life Data

9477325

Source:http://linkedlifedata.com/resource/pubmed/id/9477325

Statements in which the resource exists.
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pubmed-article:9477325pubmed:abstractTextThe Hox genes encode homeobox transcription factors that control the formation of segment specific structures in the anterior-posterior axis. HOX proteins regulate the transcription of downstream targets acting both as repressors and as activators. Due to the similarity of their homeoboxes it is likely that much of the specificity of HOX proteins is determined by interaction with transcriptional cofactors, but few HOX cofactor proteins have yet been described. Here I present genetic evidence showing that lines, a segment polarity gene of Drosophila, is required for the function of the Abdominal-B protein. In lines mutant embryos Abdominal-B protein expression is normal but incapable of promoting its normal functions: formation of the posterior spiracles and specification of an eighth abdominal denticle belt. These defects arise because in lines mutant embryos the Abdominal-B protein cannot activate its direct target empty spiracles or other downstream genes while it can function as a repressor of Ultrabithorax and abdominal-A. The lines gene seems to be required exclusively for Abdominal-B but not for the function of other Hox genes.lld:pubmed
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pubmed-article:9477325pubmed:dateRevised2010-8-25lld:pubmed
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pubmed-article:9477325pubmed:articleTitleThe lines gene of Drosophila is required for specific functions of the Abdominal-B HOX protein.lld:pubmed
pubmed-article:9477325pubmed:affiliationDepartment of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK. jec24@cam.ac.uklld:pubmed
pubmed-article:9477325pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:9477325pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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