rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
2
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pubmed:dateCreated |
1998-4-3
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pubmed:abstractText |
The role of the inhibitory neurotransmitter gamma aminobutyric acid (GABA) in schizophrenia has previously been investigated using postmortem material. Recently, using single photon emission tomography (SPET) with the selective benzodiazepine antagonist 123I-Iomazenil as the radioligand, we have demonstrated an in vivo relationship between reduced GABAA/benzodiazepine receptor binding and the severity of positive symptomatology in schizophrenia. The present study aimed to build on this using the same in vivo scanning techniques, and relating findings to cognitive functioning.
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pubmed:grant |
|
pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jan
|
pubmed:issn |
0006-3223
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
15
|
pubmed:volume |
43
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
107-17
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pubmed:dateRevised |
2009-9-29
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pubmed:meshHeading |
pubmed-meshheading:9474443-Adult,
pubmed-meshheading:9474443-Cognition,
pubmed-meshheading:9474443-Female,
pubmed-meshheading:9474443-Flumazenil,
pubmed-meshheading:9474443-Humans,
pubmed-meshheading:9474443-Image Processing, Computer-Assisted,
pubmed-meshheading:9474443-Iodine Radioisotopes,
pubmed-meshheading:9474443-Male,
pubmed-meshheading:9474443-Neuropsychological Tests,
pubmed-meshheading:9474443-Psychiatric Status Rating Scales,
pubmed-meshheading:9474443-Psychomotor Performance,
pubmed-meshheading:9474443-Receptors, GABA-A,
pubmed-meshheading:9474443-Schizophrenia,
pubmed-meshheading:9474443-Schizophrenic Psychology,
pubmed-meshheading:9474443-Tomography, Emission-Computed, Single-Photon
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pubmed:year |
1998
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pubmed:articleTitle |
Cognitive functioning and GABAA/benzodiazepine receptor binding in schizophrenia: a 123I-iomazenil SPET study.
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pubmed:affiliation |
Department of Psychology, University of London, United Kingdom.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't
|