|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
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|
pubmed:dateCreated |
1998-4-3
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|
pubmed:abstractText |
How clozapine exerts superior antipsychotic efficacy in treatment-resistant schizophrenia is not known. Moderate (rather than "full") occupancy of D2 postsynaptic receptors may be crucial, perhaps by achieving a more effective D1/D2 or serotonin-2a/D2 ratio. The objective of this study was to test the moderate occupancy hypothesis of clozapine's superior efficacy.
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pubmed:grant |
|
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pubmed:commentsCorrections |
|
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
0006-3223
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
43
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
79-83
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|
pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
|
|
pubmed:year |
1998
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|
pubmed:articleTitle |
Hypothesis testing: is clozapine's superior efficacy dependent on moderate D2 receptor occupancy?
|
|
pubmed:affiliation |
Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore 21228, USA.
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|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.
|
