Linked Life Data

9473413

Source:http://linkedlifedata.com/resource/pubmed/id/9473413

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1998-3-16
pubmed:abstractText
The purpose of this study was to determine whether spontaneous oscillations in blood flow (relative red blood cell flux) measured by laser Doppler flowmetry (LDF) in the cat optic nerve head were related to fluctuations in nitric oxide (NO) measured with electrochemical sensors (n = 16 cats). Power spectral densities for the magnitude and frequency of LDF and NO fluctuations were determined by discrete Fourier transform analysis. Complex behavior was found for both LDF and NO oscillations with broad spectra containing peaks at multiple frequencies. Most of the power was in the low-frequency range (<10 cycles/min). Spectra were also obtained after administering NO synthase inhibitors (l-nitroarginine, L-NA, n = 6 cats; l-nitroarginine methyl ester, L-NAME, n = 5 cats). Both inhibitors caused a decrease in blood flow, basal NO levels, and amplitude of NO fluctuations. There was little change in amplitude for blood flow oscillations, with some enhancement at the lowest frequencies. We conclude that NO is not required for vasomotion and that spontaneous, low-frequency NO fluctuations observed in the cat optic nerve head are a passive phenomenon caused by natural variations in shear stresses.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0026-2862
pubmed:author
pubmed:copyrightInfo
Copyright 1998 Academic Press.
pubmed:issnType
Print
pubmed:volume
55
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
103-12
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Vasomotion and spontaneous low-frequency oscillations in blood flow and nitric oxide in cat optic nerve head.
pubmed:affiliation
Department of Bioengineering, University of Pennsylvania School of Medicine, Philadelphia 19104-6068, USA. buerk@seas.upenn.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.