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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1998-3-13
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pubmed:abstractText |
The biological functions of macrophage-inflammatory protein 1alpha (MIP-1alpha) include the regulation of inflammatory processes and the inhibition of early hematopoiesis. We investigated the regulation of MIP-1alpha in various cell types in response to IFN-alpha and IL-4 by mRNA analysis and examination of MIP-1alpha protein levels in culture supernatants. In peripheral blood mononuclear cells (PBMNCs) and purified monocytes, IFN-alpha induced MIP-1alpha mRNA expression and stimulated MIP-1alpha secretion in LPS-activated monocytes to almost twice the value observed with LPS alone, whereas IL-4 caused a reduction by 80-95%. The stimulatory effect of IFN-alpha on MIP-1alpha production appeared to be dominant over its inhibition by IL-4. This effect was most pronounced after prolonged incubation periods. In fibroblasts obtained from human foreskin, IFN-alpha in combination with IL-1 stimulated MIP-1alpha secretion to more than three times the level obtained with IL-1. Stimulation of MIP-1alpha expression by IFN-alpha may indirectly influence inflammatory processes and the regulation of early hematopoiesis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0301-472X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
117-23
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:9472801-Cells, Cultured,
pubmed-meshheading:9472801-Chemokine CCL3,
pubmed-meshheading:9472801-Chemokine CCL4,
pubmed-meshheading:9472801-Fibroblasts,
pubmed-meshheading:9472801-Gene Expression Regulation,
pubmed-meshheading:9472801-Humans,
pubmed-meshheading:9472801-Infant, Newborn,
pubmed-meshheading:9472801-Interferon-alpha,
pubmed-meshheading:9472801-Interleukin-1,
pubmed-meshheading:9472801-Kinetics,
pubmed-meshheading:9472801-Macrophage Inflammatory Proteins,
pubmed-meshheading:9472801-Male,
pubmed-meshheading:9472801-Monocytes,
pubmed-meshheading:9472801-RNA, Messenger,
pubmed-meshheading:9472801-Recombinant Proteins,
pubmed-meshheading:9472801-Skin,
pubmed-meshheading:9472801-Transcription, Genetic
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pubmed:year |
1998
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pubmed:articleTitle |
Induction of macrophage-inflammatory protein 1alpha (MIP-1alpha) by interferon-alpha.
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pubmed:affiliation |
IIIrd Department of Medicine, The Johannes Gutenberg University School of Medicine, Mainz, Germany.
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pubmed:publicationType |
Journal Article
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