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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1998-4-14
|
| pubmed:abstractText |
To evaluate the importance of mutations of p53 and K-ras genes in the prognosis of patients with non-small cell lung cancer, one hundred and forty-four patients who underwent surgery were studied. DNA was extracted from frozen specimens. Polymerase chain reaction-single strand conformation polymorphism and sequencing were performed to investigate mutations of p53 from exon 5 to 8, and mutations of exon 1 of K-ras. Mutations of p53 gene occurred in 35. 4% of patients, and mutations of the K-ras gene in 8.3%. The overall survival rate of non-small cell lung cancer patients with wild-type K-ras was better than that of patients whose tumors had mutations of K-ras (P=0.0330). Among patients with adenocarcinoma of the lung, the overall survival rate of patients with wild-type p53 was strikingly better than that of patients whose tumors had mutations of p53 (P=0.0234). Multivariate analysis with the Cox regression model of all patients with non-small cell lung cancer and those with adenocarcinoma indicated that mutations of K-ras best correlated with the overall survival rate (P=0.0005 and P=0.0361, respectively). In conclusion, evaluation of mutations of both the p53 and K-ras genes in the lung tumors might be useful for assessing the prognosis, especially in patients with adenocarcinoma.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
1019-6439
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
12
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
553-63
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:9472092-Adenocarcinoma,
pubmed-meshheading:9472092-Aged,
pubmed-meshheading:9472092-Aged, 80 and over,
pubmed-meshheading:9472092-Carcinoma, Large Cell,
pubmed-meshheading:9472092-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:9472092-Carcinoma, Squamous Cell,
pubmed-meshheading:9472092-Codon,
pubmed-meshheading:9472092-DNA, Neoplasm,
pubmed-meshheading:9472092-Exons,
pubmed-meshheading:9472092-Female,
pubmed-meshheading:9472092-Genes, p53,
pubmed-meshheading:9472092-Genes, ras,
pubmed-meshheading:9472092-Humans,
pubmed-meshheading:9472092-Lung Neoplasms,
pubmed-meshheading:9472092-Lymphatic Metastasis,
pubmed-meshheading:9472092-Male,
pubmed-meshheading:9472092-Middle Aged,
pubmed-meshheading:9472092-Multivariate Analysis,
pubmed-meshheading:9472092-Neoplasm Staging,
pubmed-meshheading:9472092-Point Mutation,
pubmed-meshheading:9472092-Polymerase Chain Reaction,
pubmed-meshheading:9472092-Polymorphism, Single-Stranded Conformational,
pubmed-meshheading:9472092-Predictive Value of Tests,
pubmed-meshheading:9472092-Prognosis,
pubmed-meshheading:9472092-Regression Analysis,
pubmed-meshheading:9472092-Risk Factors,
pubmed-meshheading:9472092-Smoking,
pubmed-meshheading:9472092-Survival Analysis
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Mutations of p53 and K-ras genes as prognostic factors for non-small cell lung cancer.
|
| pubmed:affiliation |
Department of Thoracic Surgery, Kitano Hospital, Tazuke Kofukai Medical Research Institute, 13-3, Kamiyamacho, Kitaku, Osaka 530, Japan.
|
| pubmed:publicationType |
Journal Article
|